	US 11,724,080 B2
	Method of implantation of cell aggregates and tissue fragments
Jens Schouenborg, Lund (SE)
Assigned to NEURONANO AB
Appl. No. 16/73,373
Filed by NEURONANO AB, Karlshamn (SE)
PCT Filed Feb. 23, 2017, PCT No. PCT/SE2017/000014 § 371(c)(1), (2) Date Jul. 27, 2018, PCT Pub. No. WO2017/146627, PCT Pub. Date Aug. 31, 2017.
Claims priority of application No. 1600070-5 (SE), filed on Feb. 26, 2016.
Prior Publication US 2019/0030310 A1, Jan. 31, 2019
This patent is subject to a terminal disclaimer.
Int. Cl. A61M 37/00 (2006.01); A61M 5/31 (2006.01); A61B 5/00 (2006.01); A61B 5/055 (2006.01); A61L 27/22 (2006.01); A61L 27/36 (2006.01); A61L 27/54 (2006.01); A61L 31/02 (2006.01); A61N 1/05 (2006.01); A61L 31/04 (2006.01)

CPC A61M 37/0069 (2013.01) [A61L 27/222 (2013.01); A61L 27/3675 (2013.01); A61L 27/54 (2013.01); A61L 31/022 (2013.01); A61L 31/04 (2013.01); A61M 5/3129 (2013.01); A61N 1/0551 (2013.01); A61B 5/055 (2013.01); A61B 5/4893 (2013.01); A61B 2576/026 (2013.01); A61M 2202/07 (2013.01); A61M 2202/09 (2013.01); A61M 2205/3306 (2013.01); A61M 2210/0693 (2013.01); A61M 2230/08 (2013.01)]

20 Claims

1. An apparatus for forming a linear channel in soft tissue for implantation of an aggregate of living cells or a soft tissue fragment, comprising an oblong rigid, non-degradable/non-dissolvable pin having a front end and a rear end and a layer comprising a dry gel forming agent disposed on a pin section and extending proximally from the front end and enclosing said pin section, wherein said layer contains less than 20% by weight of water, wherein the pin is sufficiently rigid to allow the pin to be inserted into soft tissue in absence of the pin's layer comprising the dry gel forming agent; wherein the pin comprises a passage extending between the pin's front end and the pin's rear end, wherein the passage is rectangular, rhomboid, trapezoid, about rectangular, about rhomboid, or about trapezoid in a radial section, wherein the pin is extractable from the gel formed by the dry gel forming agent after insertion of the apparatus into the soft tissue to define the linear channel, wherein the gel formed in the linear channel can receive the aggregate of living cells or the soft tissue fragment, and wherein the gel prevents shrinkage of the channel radially inwardly and stabilizes the geometry of the channel formed by the apparatus after extraction of the pin.