US 11,724,030 B2
Method and apparatus for diagnosis and treatment of microvascular dysfunction
Robert S. Schwartz, Inver Grover Heights, MN (US); Jon Helge Hoem, Baar (CH); and Martin T. Rothman, Santa Rosa, CA (US)
Assigned to CorFlow Therapeutics AG, Baar (CH)
Filed by CorFlow Therapeutics AG, Baar (CH)
Filed on Sep. 20, 2019, as Appl. No. 16/577,962.
Claims priority of provisional application 62/734,364, filed on Sep. 21, 2018.
Prior Publication US 2020/0093991 A1, Mar. 26, 2020
Int. Cl. A61M 5/172 (2006.01); A61B 5/00 (2006.01); A61M 5/142 (2006.01); A61M 25/00 (2006.01); A61B 17/22 (2006.01)
CPC A61M 5/1723 (2013.01) [A61B 5/6853 (2013.01); A61M 5/142 (2013.01); A61M 25/007 (2013.01); A61B 2017/22051 (2013.01); A61B 2017/22084 (2013.01); A61M 2005/1726 (2013.01); A61M 2230/30 (2013.01)] 20 Claims
OG exemplary drawing
 
1. A method for measuring microvascular dysfunction in an organ or limb, the method comprising:
providing an apparatus for providing controlled flow infusion of at least a first solution to a portion of a vessel for assessment of microvascular function, the apparatus comprising a pressure sensor, a catheter having an infusion lumen configured to deliver infusate, an expandable structure disposed on the catheter, an infusion pump in communication with infusion lumen of the catheter, and a controller in communication with the infusion pump and the pressure sensor, wherein the infusate comprises the first solution;
expanding the expandable structure;
directing the infusion pump using the controller to deliver the first solution via the infusion lumen in a stepwise manner, the first solution delivered in a first step having a first flow rate, followed by a second step having a second flow rate;
receiving signals from the pressure sensor at the controller, the signals indicative of a first pressure response while the first solution is being delivered at the first flow rate and a second pressure response while the first solution is being delivered at the second flow rate;
determining a linear pressure-flow relationship based on the first flow rate, the first pressure response, the second flow rate, and the second pressure response; and
determining a dynamic microvascular resistance based on the linear pressure-flow relationship.