	US 11,724,015 B2
	Method and device for purification of blood from circulating cell free DNA
Kirill Surkov, St Petersburg (RU)
Assigned to SANTERSUS AG, Zürich (CH)
Appl. No. 16/648,045
Filed by SANTERSUS AG, Zürich (CH)
PCT Filed Sep. 17, 2018, PCT No. PCT/EP2018/075014 § 371(c)(1), (2) Date Mar. 17, 2020, PCT Pub. No. WO2019/053243, PCT Pub. Date Mar. 21, 2019.
Claims priority of provisional application 62/559,822, filed on Sep. 18, 2017.
Prior Publication US 2020/0261639 A1, Aug. 20, 2020
Int. Cl. A61M 1/34 (2006.01)

CPC A61M 1/3496 (2013.01) [A61M 1/3486 (2014.02); A61M 2202/0415 (2013.01)]

18 Claims

1. A device configured to perform apheresis comprising one or more affinity matrices, wherein said one or more affinity matrices are capable of capturing nucleosome-bound cell free DNA (cfDNA), exosome-bound cfDNA, and unbound cfDNA from blood or plasma of a subject, wherein at least one of the one or more affinity matrices comprises an H1 histone protein.