US 11,723,991 B2
Radiopharmaceutical compositions
David Jonathan Barnett, Stevenage (GB)
Assigned to SERAC HEALTHCARE LIMITED, London (GB)
Filed by SERAC HEALTHCARE LIMITED, London (GB)
Filed on Aug. 13, 2020, as Appl. No. 16/992,917.
Application 16/992,917 is a continuation of application No. 13/811,936, granted, now 10,758,635, previously published as PCT/EP2011/062897, filed on Jul. 27, 2011.
Claims priority of provisional application 61/367,992, filed on Jul. 27, 2010.
Prior Publication US 2021/0060189 A1, Mar. 4, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 51/08 (2006.01); A61K 51/04 (2006.01)
CPC A61K 51/088 (2013.01) [A61K 51/0478 (2013.01); A61K 51/082 (2013.01)] 18 Claims
 
1. A stabilized non-radioactive kit for the preparation of a 99mTc-maraciclatide radiopharmaceutical composition, said kit comprising:
(a) maraciclatide;
(b) para-aminobenzoic acid sodium salt in an amount between 100 to 600 μg;
(c) stannous chloride dihydrate;
(d) methylene diphosphonic acid;
(e) a buffer comprising sodium hydrogen carbonate in an amount of approximately 1800 μg; and
wherein all the components of said kit are lyophilized and stored in a single container; and
wherein the components are present in an amount such that reconstitution in sterile water for injection produces a composition with a pH between 6.5 and 9.5.