CPC A61K 39/39591 (2013.01) [A61K 9/0019 (2013.01); A61K 39/3955 (2013.01); A61K 45/06 (2013.01); A61K 47/02 (2013.01); A61K 47/12 (2013.01); A61K 47/183 (2013.01); A61K 47/22 (2013.01); A61K 47/26 (2013.01); A61K 47/34 (2013.01); C07K 16/2803 (2013.01); C07K 16/2818 (2013.01); C07K 16/2827 (2013.01); A61J 1/1412 (2013.01); A61K 2039/54 (2013.01); A61K 2039/545 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C07K 2317/565 (2013.01)] | 24 Claims |
1. A pharmaceutical composition comprising:
(a) about 80 mg of an anti-LAG-3 antibody or antigen binding fragment thereof comprising CDR1, CDR2, and CDR3 domains of the heavy chain variable region having the sequence set forth in SEQ ID NO:3, and CDR1, CDR2, and CDR3 domains of the light chain variable region having the sequence set forth in SEQ ID NO:5;
(b) about 240 mg of an anti-PD-1 antibody or antigen binding fragment thereof comprising CDR1, CDR2, and CDR3 domains of the heavy chain variable region having the sequence set forth in SEQ ID NO:19, and CDR1, CDR2, and CDR3 domains of the light chain variable region having the sequence set forth in SEQ ID NO:21;
(c) about 20 mM of histidine buffer;
(d) about 250 mM of sucrose;
(e) about 20 μM of DTPA; and
(f) about 0.05% (w/v) of polysorbate 80;
wherein the pharmaceutical composition has a pH of about 5.8.
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