US 11,723,958 B2
Microparticle-based enzyme systems for selective removal of target molecules
Felix Moser, Cambridge, MA (US); and David Benjamin, Cambridge, MA (US)
Assigned to SYNLIFE, INC., Cambridge, MA (US)
Filed by SynLife, Inc., Cambridge, MA (US)
Filed on Apr. 21, 2020, as Appl. No. 16/854,653.
Claims priority of provisional application 62/958,935, filed on Jan. 9, 2020.
Prior Publication US 2021/0213107 A1, Jul. 15, 2021
Int. Cl. A61K 38/44 (2006.01); A61P 39/00 (2006.01); A61K 9/127 (2006.01)
CPC A61K 38/44 (2013.01) [A61K 9/127 (2013.01); A61P 39/00 (2018.01); C12Y 106/03001 (2013.01)] 9 Claims
OG exemplary drawing
 
1. A method for continuously removing ethanol from a body cavity or blood of a human subject by converting the ethanol to acetate, the method comprising administering to the subject a composition of liposomes comprising an aqueous phase comprising (i) a system for generating NAD+ from NADH consisting of NADH oxidase (NOX) and oxygen, and (ii) NAD+-dependent enzymes that convert ethanol to acetate, said enzymes consisting of alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase (ALDH).