CPC A61K 38/193 (2013.01) [A61K 9/0019 (2013.01); A61K 9/0024 (2013.01); A61K 9/06 (2013.01); A61K 31/765 (2013.01); A61K 38/385 (2013.01); A61K 39/04 (2013.01); A61K 39/07 (2013.01); A61K 39/39541 (2013.01); A61K 41/0028 (2013.01); A61K 41/0052 (2013.01); A61K 47/10 (2013.01); A61K 47/34 (2013.01); A61K 47/36 (2013.01); A61P 35/00 (2018.01); C07K 16/2818 (2013.01); A61K 2039/505 (2013.01); A61K 2039/522 (2013.01); A61K 2039/54 (2013.01); A61K 2039/55522 (2013.01); A61K 2039/585 (2013.01); A61K 2039/82 (2018.08); C07K 2317/76 (2013.01)] | 13 Claims |
1. A thermosensitive mucoadhesive polymeric hydrogel comprising:
at least one thermosensitive copolymer, consisting of poloxamer 407 at a concentration of 21% w/v, in one aqueous solution; and
xantham gum at a concentration of 0.1% w/v;
wherein said thermosensitive polymeric hydrogel further comprises at least one immunostimulatory adjuvant and at least one cytokine and/or at least one chemokine and/or at least one heat shock protein, and wherein said hydrogel presents a gelification temperature between 21° C. and 28° C., and can be administered as a flowable liquid but will gelify on the tissue of interest.
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