CPC A61K 35/34 (2013.01) [A61K 31/453 (2013.01); A61K 45/06 (2013.01); A61L 31/16 (2013.01); C12Y 303/0201 (2013.01)] | 16 Claims |
1. A method of increasing, improving and/or promoting the survival, engraftment, and/or integration of transplanted stem cells in a tissue of a subject in need thereof, comprising:
a) exposing a population stem cells in vitro to an agent that increases the production and/or level of epoxy fatty acids (EpFA), or mimics thereof, under conditions and for a time sufficient to increase epoxy fatty acids (EpFA) and/or inhibit soluble epoxide hydrolase in the stem cells, thereby producing preconditioned stem cells; and
b) administering to the subject the preconditioned stem cells, wherein the stem cells are selected from multipotent stem cells, pluripotent stem cells, and induced pluripotent stem cells.
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