	US 11,723,926 B2
	Senescent cell-associated antigen-binding domains, antibodies and chimeric antigen receptors comprising the same, and uses thereof
Müge Ogrunc, Paris (FR); and Thierry Mathieu, Brussels (BE)
Assigned to StarkAge Therapeutics, Lille (FR)
Filed by StarkAge Therapeutics, Lille (FR)
Filed on Sep. 25, 2020, as Appl. No. 17/32,510.
Application 17/032,510 is a continuation in part of application No. 16/585,256, filed on Sep. 27, 2019, abandoned.
Claims priority of application No. 19200182 (EP), filed on Sep. 27, 2019.
Prior Publication US 2022/0193130 A1, Jun. 23, 2022
Int. Cl. A61K 35/17 (2015.01); C07K 16/28 (2006.01); C12N 5/0783 (2010.01)

CPC A61K 35/17 (2013.01) [C07K 16/2896 (2013.01); C12N 5/0636 (2013.01); C07K 2317/24 (2013.01); C07K 2317/31 (2013.01)]

15 Claims

1. A DPP4-binding domain, comprising a combination of three heavy chain variable region (HCVR)'s complementary-determining regions (CDRs) and three light chain variable region (LCVR)'s CDRs, said combination being as defined in any row of the table below, wherein the CDRs are defined by their SEQ ID NO:


	V_H-	V_H-	V_H-	V_L-	V_L-	V_L-
Clone’s name	CDR1	CDR2	CDR3	CDR1	CDR2	CDR3

5826-13-R3A-A10	107	119	137	146	157	170
5826-13-R3A-B1	108	120	138	147	158	171
5826-13-R3A-B3	108	121	138	147	159	171
5826-13-R3A-D5	109	122	139	148	160	172
5826-13-R3A-D6	108	123	138	149	159	171
5826-13-R4A-E2	108	124	138	147	159	171
5826-13-R4A-E6	110	125	140	146	161	170
5826-13-R4A-E9	108	126	141	149	159	171
5826-13-R4A-F10	108	126	138	150	159	171
5826-13-R4A-G11	108	126	138	150	159	171
5826-13-R4A-G12	111	127	138	151	159	171
5826-13-R4A-H1	110	128	140	146	162	170
5826-13-R4A-H2	108	126	141	149	159	171
5826-13-R4A-H3	108	126	138	149	159	173
5826-13-R4A-H4	112	125	140	146	162	170
5826-13-R4A-H5	108	127	138	147	159	171
5826-13-R4A-H6	108	127	142	147	159	171
5826-13-R4A-H9	108	123	138	149	159	171
5826-13-R4A-H10	110	125	140	146	162	170
5826-13-R4A-H11	110	128	140	146	162	170
5826-13-R4A-H12	110	125	140	146	163	170.