US 11,723,916 B2
Multi-functional hemocompatible porous polymer bead sorbent for removing protein based toxins and potassium from biological fluids
Thomas Golobish, Princeton, NJ (US); Maryann Gruda, Yardley, PA (US); Tamaz Guliashvili, Philadelphia, PA (US); Pamela O'Sullivan, Manalapan, NJ (US); Andrew Scheirer, Hoboken, NJ (US); Vi Dan, East Brunswick, NJ (US); Wei-Tai Young, Hillsborough, NJ (US); Vincent Capponi, Lawrenceville, NJ (US); and Phillip Chan, Cherry Hill, NJ (US)
Assigned to CytoSorbents Corporation, Monmouth Junction, NJ (US)
Filed by CytoSorbents Corporation, Monmouth Junction, NJ (US)
Filed on Jun. 8, 2021, as Appl. No. 17/341,912.
Application 17/341,912 is a continuation of application No. 15/769,361, granted, now 11,040,061, previously published as PCT/US2016/058019, filed on Oct. 21, 2016.
Claims priority of provisional application 62/245,071, filed on Oct. 22, 2015.
Prior Publication US 2021/0401874 A1, Dec. 30, 2021
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/795 (2006.01); A61M 5/165 (2006.01); B01J 20/26 (2006.01); B01J 39/20 (2006.01); B01J 20/28 (2006.01); A61K 47/20 (2006.01); A61K 47/26 (2006.01); A61M 1/36 (2006.01); A61M 5/14 (2006.01)
CPC A61K 31/795 (2013.01) [A61K 47/20 (2013.01); A61K 47/26 (2013.01); A61M 5/165 (2013.01); B01J 20/264 (2013.01); B01J 20/267 (2013.01); B01J 20/28069 (2013.01); B01J 39/20 (2013.01); A61M 1/3679 (2013.01); A61M 5/14 (2013.01)] 26 Claims
OG exemplary drawing
 
1. A biocompatible polymer system comprising at least one polymer, said polymer comprising (i) a plurality of pores and (ii) a sulfonic acid salt functionality;
wherein the polymer's pore structure has a total volume of pore sizes in the range of from 10 Å to 40,000 Å greater than 0.1 cc/g and less than 5.0 cc/g dry polymer; and
wherein the polymer is in the form of a crosslinked polymer or a porous polymer; wherein the crosslinked polymer or porous polymer has been sulfonated under mild conditions that retain residual functionality of any unreacted double bonds and chloromethyl groups.