CPC A61K 31/726 (2013.01) [A01N 43/16 (2013.01); A01N 59/00 (2013.01); A61K 31/7036 (2013.01); A61K 47/595 (2017.08); C08B 37/0063 (2013.01); C12N 15/76 (2013.01); C07H 15/234 (2013.01)] | 15 Claims |
1. A hyperbranched polyaminoglycoside, comprising a first aminoglycoside unit comprising Formula II:
wherein each of R1, R2, R3, R4, R5, R6, R9, and R10 is independently selected from —H or represents a covalent bond to one or more linking units;
wherein a linking unit of the one or more linking units is represented by the following structure:
wherein at least one linking unit forms a covalent bridge between the first aminoglycoside unit and a second aminoglycoside unit; and
wherein at least one aminoglycoside unit of the hyperbranched polyaminoglycoside is derived from kanamycin;
wherein at least one aminoglycoside unit of the hyperbranched polyaminoglycoside comprises one or more terminal units selected from:
and
wherein at least a secondary amine of the hyperbranched polyaminoglycoside comprises a N-diazeniumdiolate NO donor.
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