US 11,723,900 B2
4-[2-(2-fluorophenoxymethyl)phenyl]piperidine compounds
Lori Jean Patterson, San Francisco, CA (US); and Eric L. Stangeland, Pacifica, CA (US)
Assigned to THERAVANCE BIOPHARMA R&D IP, LLC, South San Francisco, CA (US)
Filed by THERAVANCE BIOPHARMA R&D IP, LLC, South San Francisco, CA (US)
Filed on Feb. 3, 2021, as Appl. No. 17/248,692.
Application 15/591,419 is a division of application No. 14/848,933, filed on Sep. 9, 2015, granted, now 9,675,599, issued on Jun. 13, 2017.
Application 14/070,887 is a division of application No. 13/631,192, filed on Sep. 28, 2012, granted, now 8,604,058, issued on Dec. 10, 2013.
Application 13/631,192 is a division of application No. 12/617,821, filed on Nov. 13, 2009, granted, now 8,304,432, issued on Nov. 6, 2012.
Application 17/248,692 is a continuation of application No. 16/903,579, filed on Jun. 17, 2020, granted, now 10,946,007.
Application 16/903,579 is a continuation of application No. 16/559,928, filed on Sep. 4, 2019, granted, now 10,722,504.
Application 16/559,928 is a continuation of application No. 16/239,265, filed on Jan. 3, 2019, granted, now 10,441,579, issued on Oct. 15, 2019.
Application 16/239,265 is a continuation of application No. 16/007,233, filed on Jun. 13, 2018, granted, now 10,206,913, issued on Feb. 19, 2019.
Application 16/007,233 is a continuation of application No. 15/591,419, filed on May 10, 2017, granted, now 10,034,870, issued on Jul. 31, 2018.
Application 14/848,933 is a continuation of application No. 14/070,887, filed on Nov. 4, 2013, granted, now 9,162,982, issued on Oct. 20, 2015.
Claims priority of provisional application 61/114,541, filed on Nov. 14, 2008.
Prior Publication US 2022/0087995 A1, Mar. 24, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/4465 (2006.01); C07D 211/22 (2006.01); C07D 211/32 (2006.01)
CPC A61K 31/4465 (2013.01) [C07D 211/22 (2013.01); C07D 211/32 (2013.01)] 5 Claims
 
1. A process for preparing a hydrochloride salt of a compound of formula 1:

OG Complex Work Unit Chemistry
the process comprising contacting a compound of the formula:

OG Complex Work Unit Chemistry
with hydrochloric acid to form a hydrochloride salt of the compound of formula 1.