US 11,723,877 B2
Microencapsulation process and product
Diane Goll, Grand Haven, MI (US); and Cecil W. Propst, Norton Shores, MI (US)
Assigned to SPI PHARMA, INC., Wilmington, DE (US)
Filed by SPI PHARMA, INC., Wilmington, DE (US)
Filed on Feb. 7, 2020, as Appl. No. 16/784,894.
Application 16/784,894 is a continuation of application No. 13/825,026, granted, now 10,561,621, previously published as PCT/US2011/052406, filed on Sep. 20, 2011.
Claims priority of provisional application 61/384,351, filed on Sep. 20, 2010.
Prior Publication US 2020/0170959 A1, Jun. 4, 2020
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/50 (2006.01); A61K 9/00 (2006.01); A61K 31/167 (2006.01); A61K 31/522 (2006.01); A61K 31/4402 (2006.01); A61K 31/451 (2006.01); A61K 31/192 (2006.01); A61K 9/20 (2006.01)
CPC A61K 9/5057 (2013.01) [A61K 9/0056 (2013.01); A61K 9/2081 (2013.01); A61K 9/501 (2013.01); A61K 9/5031 (2013.01); A61K 9/5036 (2013.01); A61K 9/5042 (2013.01); A61K 9/5052 (2013.01); A61K 31/167 (2013.01); A61K 31/192 (2013.01); A61K 31/4402 (2013.01); A61K 31/451 (2013.01); A61K 31/522 (2013.01)] 13 Claims
 
1. A composition comprising:
a core material having a taste value;
a polymeric coating substantially surrounding the core material, the polymeric coating comprising a coacervated polymer material comprising a cationic polymer, the cationic polymer comprising gelatin, and an anionic polymer mixture, the anionic polymer mixture comprising a long chain polyphosphate in combination with a medium chain polyphosphate, wherein the ratio of the cationic polymer to the anionic polymer mixture ranges from 8:1 to 11:1 and the polymeric coating has a thickness selected from between 1 μm to 20 μm, wherein the thickness of the polymeric coating is uniform and varies over a range from 0.2 μm to 2.0 μm;
wherein the composition provides a controlled release of a portion of the core material which is taste masked over a time period ranging from 0.5 minute to 2 minutes in the oral cavity and provides release of the remaining core material in a gastrointestinal tract.