	US 11,723,869 B2
	Freeze-dried product and gas-filled microvesicles suspension
Philippe Bussat, Pers-Jussy (FR); Anne Lassus, Veyrier (CH); Jean Brochot, Cruseilles (FR); Michel Schneider, Troinex (CH); and Feng Yan, Grand Lancy (CH)
Assigned to Bracco Suisse SA, Cadempino (CH)
Filed by Bracco Suisse SA, Cadempino (CH)
Filed on Jul. 25, 2022, as Appl. No. 17/872,974.
Application 17/872,974 is a continuation of application No. 17/611,034, granted, now 11,426,352, previously published as PCT/EP2020/063559, filed on May 14, 2020.
Application 17/611,034 is a continuation of application No. 16/788,083, filed on Feb. 11, 2020, abandoned.
Application 16/788,083 is a continuation in part of application No. 16/688,540, filed on Nov. 19, 2019, abandoned.
Application 16/688,540 is a continuation in part of application No. 16/413,526, filed on May 15, 2019, abandoned.
Prior Publication US 2022/0354795 A1, Nov. 10, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/19 (2006.01); A61K 9/127 (2006.01); A61K 49/22 (2006.01)

CPC A61K 9/19 (2013.01) [A61K 9/1271 (2013.01); A61K 9/1277 (2013.01); A61K 49/223 (2013.01)]

20 Claims

1. A suspension of gas-filled microvesicles comprising a freeze-dried product dissolved in a pharmaceutically acceptable liquid carrier, said freeze-dried product comprising 1,2-distearoyl-sn-glycero-3-phosphocholine (DSPC), dipalmitoylphosphatidylglycerol sodium salt (DPPG-Na), palmitic acid and polyethylene glycol 4000 (PEG4000), wherein said suspension has a value of critical pressure (Pc50) of at least 20 kPa, and wherein the microvesicles are filled with a SF₆gas.