US 11,723,617 B2
Method and system for imaging
Andreas Fouras, Woodland Hills, CA (US); and Chaminda Rajeev Samarage, Melbourne (AU)
Assigned to 4DMedical Limited, Melbourne (AU)
Filed by 4DMEDICAL LIMITED, Melbourne (AU)
Filed on Feb. 28, 2022, as Appl. No. 17/683,064.
Application 17/683,064 is a division of application No. 16/081,854, granted, now 11,278,256, previously published as PCT/AU2017/000054, filed on Feb. 24, 2017.
Claims priority of application No. 2016900354 (AU), filed on Feb. 3, 2016; and application No. 2016900817 (AU), filed on Mar. 4, 2016.
Prior Publication US 2022/0183646 A1, Jun. 16, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 6/00 (2006.01); G06T 7/143 (2017.01); G06T 7/00 (2017.01); G06T 7/187 (2017.01); G06T 7/62 (2017.01); A61B 5/08 (2006.01); A61B 5/02 (2006.01); G06T 7/35 (2017.01); G06T 7/11 (2017.01); A61B 6/03 (2006.01); A61B 5/026 (2006.01); A61B 5/00 (2006.01); A61B 5/113 (2006.01)
CPC A61B 6/5217 (2013.01) [A61B 5/02007 (2013.01); A61B 5/08 (2013.01); A61B 6/032 (2013.01); A61B 6/481 (2013.01); A61B 6/504 (2013.01); A61B 6/507 (2013.01); A61B 6/508 (2013.01); A61B 6/541 (2013.01); G06T 7/0012 (2013.01); G06T 7/0016 (2013.01); G06T 7/11 (2017.01); G06T 7/143 (2017.01); G06T 7/187 (2017.01); G06T 7/35 (2017.01); G06T 7/62 (2017.01); A61B 5/026 (2013.01); A61B 5/113 (2013.01); A61B 5/7285 (2013.01); A61B 2576/02 (2013.01); G06T 2207/10076 (2013.01); G06T 2207/10081 (2013.01); G06T 2207/10088 (2013.01); G06T 2207/10136 (2013.01); G06T 2207/20016 (2013.01); G06T 2207/20024 (2013.01); G06T 2207/20076 (2013.01); G06T 2207/30061 (2013.01); G06T 2207/30101 (2013.01); G06T 2207/30104 (2013.01); G06T 2207/30172 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A method of calculating a ventilation/perfusion ratio from at least one in vivo lung image comprising a vasculature tree and acquired in the absence of contrast agent and a time series of lung images, the method comprising:
applying a filter to the at least one in vivo lung image comprising the vasculature tree to provide a probability field and a scale field;
performing vessel segmentation on the probability field to extract a segmented vasculature tree from the probability field;
mapping the scale field to the segmented vasculature tree to quantify a geometry of the vasculature tree;
measuring a motion of a portion of the lung from the time series of lung images; and
comparing the motion of the portion of the lung to the geometry of the vasculature tree in the region of the portion of the lung to obtain the ventilation/perfusion ratio.