	US 11,723,569 B2
	Methods of identifying schizophrenia patients at risk for relapse
Dai Wang, Bridgewater, NJ (US); Srihari Gopal, Belle Mead, NJ (US); Vaibhav Narayan, Princeton, NJ (US); Adam Savitz, Greenwich, CT (US); and Susan Baker, Pennington, NJ (US)
Assigned to JANSSEN PHARMACEUTICA NV, Beerse (BE)
Filed by JANSSEN PHARMACEUTICA NV, Beerse (BE)
Filed on Nov. 21, 2017, as Appl. No. 15/818,903.
Claims priority of provisional application 62/434,587, filed on Dec. 15, 2016.
Claims priority of provisional application 62/425,257, filed on Nov. 22, 2016.
Prior Publication US 2018/0140242 A1, May 24, 2018
Int. Cl. A61B 5/16 (2006.01); G01N 33/74 (2006.01); A61K 31/519 (2006.01); A61B 5/145 (2006.01); G01N 33/68 (2006.01); A61P 25/18 (2006.01); A61B 5/00 (2006.01)

CPC A61B 5/167 (2013.01) [A61B 5/165 (2013.01); A61K 31/519 (2013.01); A61P 25/18 (2018.01); G01N 33/6869 (2013.01); G01N 33/6893 (2013.01); G01N 33/743 (2013.01); A61B 5/14546 (2013.01); A61B 5/4088 (2013.01); A61B 5/4839 (2013.01); A61B 5/7275 (2013.01); G01N 2333/5412 (2013.01); G01N 2333/7155 (2013.01); G01N 2800/302 (2013.01); G01N 2800/50 (2013.01); G01N 2800/54 (2013.01)]

20 Claims

1. A method of treating a patient at risk for a schizophrenia relapse comprising:

a) scoring a patient on the following 7 Positive and Negative Syndrome Scale (PANSS) items before the schizophrenia relapse:

P1 (delusions),

P2 (conceptual disorganization),

P3 (hallucinations),

P4 (excitement),

P6 (suspiciousness),

G2 (anxiety), and

G4 (tension);

b) determining an amount of change in the score of the 7 PANSS items as compared to a previous PANSS score for the patient,

wherein an increase of at least 1 point in all 7 of the 7 PANSS items identifies the patient as at risk for the schizophrenia relapse; and

c) administering a pharmaceutical agent to the patient who has been found to be at risk in step (b) to decrease likelihood of progression to the relapse or severity of the relapse.