US 11,723,547 B2
System and method for monitoring absolute blood flow
Jason Sutin, Cambridge, MA (US); Maria Angela Franceschini, Winchester, MA (US); and David Boas, Winchester, MA (US)
Assigned to The General Hospital Corporation, Boston, MA (US)
Filed by The General Hospital Corporation, Boston, MA (US)
Filed on Jun. 21, 2022, as Appl. No. 17/844,958.
Application 17/844,958 is a continuation of application No. 15/564,686, granted, now 11,395,602, previously published as PCT/US2016/026925, filed on Apr. 11, 2016.
Claims priority of provisional application 62/145,087, filed on Apr. 9, 2015.
Prior Publication US 2022/0361764 A1, Nov. 17, 2022
This patent is subject to a terminal disclaimer.
Int. Cl. A61B 5/0205 (2006.01); A61B 5/026 (2006.01); A61B 5/00 (2006.01); A61B 5/03 (2006.01); A61B 5/318 (2021.01); A61B 5/369 (2021.01); A61B 5/029 (2006.01); A61B 5/021 (2006.01); A61B 5/08 (2006.01); A61B 5/145 (2006.01); A61B 5/1455 (2006.01)
CPC A61B 5/031 (2013.01) [A61B 5/0075 (2013.01); A61B 5/0205 (2013.01); A61B 5/029 (2013.01); A61B 5/0261 (2013.01); A61B 5/318 (2021.01); A61B 5/369 (2021.01); A61B 5/6814 (2013.01); A61B 5/7246 (2013.01); A61B 5/7278 (2013.01); A61B 5/021 (2013.01); A61B 5/08 (2013.01); A61B 5/14546 (2013.01); A61B 5/14552 (2013.01); A61B 2562/0238 (2013.01)] 13 Claims
OG exemplary drawing
 
1. A system for non-invasively estimating a blood flow index of a vascular region in a subject using optical data, the system comprising:
an optical coupling system comprising a source probe and a detector probe configured to transmit to and receive light signals from one or more locations about a subject;
an optical processing system comprising a detector configured to generate optical data using the received light signals;
a computer programmed to:
receive from the optical processing system the optical data associated with a vascular region;
determine, using the optical data, a blood flow index;
estimate a blood flow using the index of blood flow; and
generate a report indicative of the blood flow of the vascular region,
wherein the optical processing system is configured to generate the optical data at a temporal resolution greater than a pulsatile frequency of a cardiac cycle,
wherein the optical data comprises pulsatile diffusion correlation spectroscopy (pDCS) data, and
wherein the pDCS data is limited to correlations of data from within individual cardiac cycles of the plurality of cardiac cycles.