US 11,723,540 B2
Device and method for in vivo photoacoustic diagnosis and photothermal purging of infected blood
Mark S. Smeltzer, Little Rock, AR (US); Vladimir Zharov, Little Rock, AR (US); and Ekaterina Galanzha, Little Rock, AR (US)
Assigned to BioVentures, LLC, Little Rock, AR (US)
Filed by Bioventures, LLC, Little Rock, AR (US)
Filed on Feb. 10, 2022, as Appl. No. 17/668,909.
Application 17/668,909 is a continuation of application No. 16/272,798, filed on Feb. 11, 2019, granted, now 11,259,705.
Application 16/272,798 is a continuation of application No. 14/668,418, filed on Mar. 25, 2015, abandoned.
Application 14/668,418 is a continuation in part of application No. PCT/US2013/061673, filed on Sep. 25, 2013.
Claims priority of provisional application 61/705,491, filed on Sep. 25, 2012.
Prior Publication US 2022/0160237 A1, May 26, 2022
Int. Cl. A61B 5/00 (2006.01); G01N 33/569 (2006.01); G01N 33/487 (2006.01); A61B 5/145 (2006.01); A61K 41/00 (2020.01); A61K 49/22 (2006.01); A61M 5/00 (2006.01)
CPC A61B 5/0095 (2013.01) [A61B 5/14525 (2013.01); A61B 5/4839 (2013.01); A61K 41/00 (2013.01); A61K 49/221 (2013.01); A61M 5/007 (2013.01); G01N 33/48728 (2013.01); G01N 33/569 (2013.01)] 23 Claims
OG exemplary drawing
 
1. A method for theranostics of a plurality of circulating target objects in blood, lymph, and other vessels of a living organism, comprising:
generating at least one series of consecutive diagnostic laser pulses with low energy and a wavelength;
delivering the laser pulses having a laser beam of elliptical shape to the circulating target objects using a lens or optical fiber;
detecting laser-induced photoacoustic, fluorescence, or scattering light signals from the circulating target objects using focused ultrasound transducers or photodiodes;
triggering, using the detected signals, a therapeutic destruction pulse of high laser energy at the same or a different wavelength to produce laser-induced nanobubbles destroying a plurality of the circulating target objects irrespective of their antibiotic resistance status; and
monitoring a frequency of detection of the photoacoustic, fluorescence or scattering signals, wherein the low energy diagnostic laser pulses are used to control the efficacy of the photothermal destruction of the circulating target objects using the frequency of detection,
wherein the circulating target objects are related to infection.