US 10,376,716 B2
Radiation therapy system with real-time magnetic resonance monitoring
Erkki Tapani Vahala, Eindhoven (NL)
Assigned to KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
Appl. No. 14/784,635
Filed by KONINKLIJKE PHILIPS N.V., Eindhoven (NL)
PCT Filed Apr. 18, 2014, PCT No. PCT/EP2014/058009
§ 371(c)(1), (2) Date Oct. 15, 2015,
PCT Pub. No. WO2014/170483, PCT Pub. Date Oct. 23, 2014.
Claims priority of application No. 13164297 (EP), filed on Apr. 18, 2013.
Prior Publication US 2016/0082288 A1, Mar. 24, 2016
Int. Cl. A61B 5/055 (2006.01); A61B 5/00 (2006.01); G01R 33/48 (2006.01); A61N 5/10 (2006.01)
CPC A61N 5/1039 (2013.01) [A61B 5/055 (2013.01); A61B 5/4836 (2013.01); A61B 5/7271 (2013.01); A61B 5/742 (2013.01); A61B 5/7405 (2013.01); A61N 5/1037 (2013.01); A61N 5/1075 (2013.01); G01R 33/4808 (2013.01); A61N 2005/1034 (2013.01); A61N 2005/1054 (2013.01); A61N 2005/1055 (2013.01); A61N 2005/1074 (2013.01)] 19 Claims
OG exemplary drawing
 
1. A magnetic resonance guided radiotherapy system comprising:
a magnetic resonance examination system configured to acquire magnetic resonance signals of a subject within an examination zone before and during radiotherapy, the magnetic resonance signals being indicative of motion of a structure of the subject;
a radiotherapy system comprising a linear accelerator with a multi-leaf collimator, the radiotherapy system configured to perform the radiotherapy on the subject in accord with a radiotherapy plan identifying linear accelerator and multi-leaf collimator positions, the radiotherapy plan generated prior to performing the radiotherapy and assuming the motion of the structure of the subject within the examination zone indicated by the magnetic resonance signals acquired before radiotherapy;
one or more computer processors programmed to:
control the radiotherapy system to perform the radiotherapy according to the radiotherapy plan,
during performing the radiotherapy, monitoring the motion of the structure of the subject in the examination zone by the magnetic resonance signals acquired of the subject during radiotherapy,
generate a quality factor comparing (1) a variation between the motion of the structure indicated by the magnetic resonance signals acquired before the radiotherapy and the motion of the structure indicated by the magnetic resonance signals acquired during the radiotherapy with (2) one or more pre-set limits related to the variation, wherein at least one of the one or more pre-set limits is determined based on a limitation of the radiotherapy system to adjust delivery of the radiotherapy during motion of the structure during the radiotherapy, the one or more pre-set limits including a delay in a control circuit that controls compensating movement of an imaging table of the magnetic resonance examination system, the radiotherapy system and the multi-leaf collimator;
recalculate the radiotherapy plan including recalculating multi-leaf collimator movement commands based on a comparison between the structure motion before radiotherapy with structure motion during delivery of the radiotherapy when the generated quality factor indicates the assumption of the motion of the structure of the subject within the examination zone indicated by the magnetic resonance signals acquired before radiotherapy is not valid; and
control the radiotherapy system to adjust radiation therapy to a patient according to the recalculated radiotherapy plan.