US 10,376,707 B2
Method for the treatment of ischemic stroke by applying an electromagnetic field
Ruggero Cadossi, Carpi (IT); and Donata Marazzi, Carpi (IT)
Assigned to IGEA S.p.A., Carpi (IT)
Filed by IGEA S.p.A., Carpi (IT)
Filed on Mar. 13, 2015, as Appl. No. 14/657,365.
Claims priority of provisional application 61/953,447, filed on Mar. 14, 2014.
Prior Publication US 2015/0258346 A1, Sep. 17, 2015
Int. Cl. A61N 2/02 (2006.01); A61N 2/00 (2006.01); A61N 2/04 (2006.01); A61N 1/40 (2006.01)
CPC A61N 2/004 (2013.01) [A61N 2/02 (2013.01); A61N 1/40 (2013.01); A61N 2/006 (2013.01)] 7 Claims
OG exemplary drawing
1. A method for treatment of cerebral ischemic stroke in a subject in need thereof comprising:
(a) identifying an ischemic area of a brain of the subject; and
(b) applying an effective electromagnetic field to the ischemic area of the brain by flowing a pulsed current in a solenoid with a pulse duration of 1.3 ms and a frequency of 75 Hz, wherein the pulse current is generated by increasing the current in a linear manner for the entire pulse duration, wherein the electromagnetic field is effective to reduce local edema, to increase neuronal survival or to reduce neuronal apoptosis, relative to a subject that has suffered a stroke but to whom the effective electromagnetic field was not applied, and wherein the electromagnetic field is applied to the ischemic area of the brain for a time of about 2 hours per day for 5 days starting from about 24 hours after occurrence of the cerebral ischemic stroke.