US 10,376,700 B2
Methods and apparatus for adjusting neurostimulation intensity using evoked responses
Juan Gabriel Hincapie Ordonez, Maple Grove, MN (US); David J. Ternes, Roseville, MN (US); Jason J. Hamann, Blaine, MN (US); and Stephen B. Ruble, Lino Lakes, MN (US)
Assigned to Cardiac Pacemakers, Inc., St. Paul, MN (US)
Filed by Cardiac Pacemakers, Inc., St. Paul, MN (US)
Filed on Jan. 19, 2016, as Appl. No. 15/537.
Application 15/000,537 is a continuation of application No. 13/156,891, filed on Jun. 9, 2011, granted, now 9,265,431.
Claims priority of provisional application 61/356,251, filed on Jun. 18, 2010.
Prior Publication US 2016/0129257 A1, May 12, 2016
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 1/36 (2006.01); A61B 5/04 (2006.01); A61B 5/00 (2006.01)
CPC A61N 1/36139 (2013.01) [A61B 5/04001 (2013.01); A61N 1/36053 (2013.01); A61N 1/36114 (2013.01); A61N 1/36117 (2013.01); A61N 1/36128 (2013.01); A61N 1/36135 (2013.01); A61B 5/4041 (2013.01); A61B 5/4047 (2013.01); A61B 5/4058 (2013.01); A61N 1/36071 (2013.01); A61N 1/36167 (2013.01)] 20 Claims
OG exemplary drawing
1. A system for delivering neurostimulation to a body having a vagus nerve and a laryngeal muscle, the system comprising:
a stimulation output circuit configured to deliver neurostimulation pulses to the vagus nerve;
an evoked response detection circuit configured to receive a physiological signal indicative of evoked responses being physiologic events evoked by the neurostimulation pulses, to control timing of one or more detection windows based on a type of a response of the evoked responses anticipated to be detected within each window of the one or more detection windows, and to detect one of the evoked responses during a detection window of the one or more detection windows for each pulse of the neurostimulation pulses delivered using the physiological signal; and
a control circuit configured to control the delivery of the neurostimulation pulses using a stimulation intensity, the control circuit including a stimulation parameter adjustor configured to adjust the stimulation intensity in response to a specified first number of the evoked responses not detected for a specified second number of the neurostimulation pulses delivered.