US 10,376,697 B2
Montage design for closed loop sensing and neurostimulation of the dorsal lateral prefrontal cortex and/or motor cortex
Matthias Ziegler, Oakton, VA (US); Jaehoon Choe, Agoura Hills, CA (US); and Matthew E. Phillips, Calabasas, CA (US)
Assigned to HRL Laboratories, LLC, Malibu, CA (US)
Filed by HRL Laboratories, LLC, Malibu, CA (US)
Filed on May 6, 2016, as Appl. No. 15/148,793.
Application 15/148,793 is a continuation in part of application No. 15/066,813, filed on Mar. 10, 2016.
Claims priority of provisional application 62/131,031, filed on Mar. 10, 2015.
Claims priority of provisional application 62/159,151, filed on May 8, 2015.
Prior Publication US 2017/0312518 A1, Nov. 2, 2017
Int. Cl. A61N 1/36 (2006.01); A61N 1/04 (2006.01); A61N 1/20 (2006.01); A61B 5/0478 (2006.01); A61B 5/00 (2006.01)
CPC A61N 1/36025 (2013.01) [A61B 5/0075 (2013.01); A61B 5/0478 (2013.01); A61B 5/4836 (2013.01); A61N 1/0456 (2013.01); A61N 1/0484 (2013.01); A61N 1/20 (2013.01); A61N 1/205 (2013.01)] 12 Claims
OG exemplary drawing
 
1. A system for automatic adjustment of neurostimulation, the system comprising:
a neural device comprising a targeted arrangement of stimulating electrodes and recording electrodes and sensors configured to record neural data and apply neurostimulation; and
one or more processors and a non-transitory memory having instructions encoded thereon such that when the instructions are executed, the one or more processors perform operations of:
accessing a set of recorded behavioral data and recorded neural data comprising behavioral and neural recordings obtained from at least one expert in a skill and behavioral and neural recordings of at least one novice in a skill;
determining stimulation parameters for a first neurostimulation based on a comparison of a first set of behavioral and neural recordings obtained from a current novice in the skill and the behavioral and neural recordings obtained from the at least one expert and the at least one novice in the skill;
causing the first neurostimulation to be applied, via the neural device, to at least one of a motor cortex and a dorsal lateral prefrontal cortex of the current novice while simultaneously obtaining a second set of behavioral and neural recordings; and
assessing skill improvement and any relative shift in locational brain activity between the first set of neural recordings and the second set of neural recordings;
adjusting the stimulation parameters and causing a second neurostimulation to be applied, whereby the second neurostimulation increases or decreases stimulation in the motor cortex relative to the first neurostimulation and increases or decreases stimulation in the dorsal lateral prefrontal cortex relative to the first neurostimulation based on the assessed skill improvement.