US 10,376,692 B2
Electroporation device and injection apparatus
Iacob Mathiesen, Oslo (NO); Torunn E. Tjelle, Oslo (NO); Knut Arvid Sorensen Rekdahl, Tarnasen (NO); and Bjorn David-Andersen, Oslo (NO)
Assigned to Inovio AS, (NO)
Filed by Iacob Mathiesen, Oslo (NO); Torunn E. Tjelle, Oslo (NO); Knut Arvid Sorensen Rekdahl, Tarnasen (NO); and Bjorn David-Andersen, Oslo (NO)
Filed on Feb. 19, 2016, as Appl. No. 15/48,314.
Application 15/048,314 is a continuation of application No. 11/985,825, filed on Nov. 16, 2007, abandoned.
Prior Publication US 2016/0213921 A1, Jul. 28, 2016
Int. Cl. A61B 8/08 (2006.01); A61M 5/46 (2006.01); A61N 1/08 (2006.01); A61N 1/32 (2006.01)
CPC A61N 1/327 (2013.01) [A61B 8/0841 (2013.01); A61M 5/46 (2013.01); A61N 1/08 (2013.01); A61N 1/325 (2013.01)] 15 Claims
OG exemplary drawing
 
1. An apparatus for injecting a fluid into body tissue, the apparatus comprising:
at least a first hollow needle and a second hollow needle each configured for receiving a voltage and acting as an electrode to propagate an electric field to electroporate the body tissue;
a fluid delivery assembly comprising:
a first syringe connected to the first hollow needle;
a second syringe connected to the second hollow needle;
a first piston that extends within the first syringe; and
a second piston that extends within the second syringe; and
an automatic insertion and injection mechanism comprising:
a first gear configured to engage a first rack; and
a second gear configured to engage a second rack, the second rack configured to engage each of the first and second pistons, the second gear configured to be driven by the first gear so as to advance the second rack,
wherein the automatic insertion and injection mechanism is configured to insert the at least the first and second hollow needles in the body tissue to a first desired depth, and to advance the at least the first and second hollow needles from the first desired depth to a second desired depth in the body tissue, and
wherein the automatic insertion and injection mechanism is further configured to automatically 1) advance the second rack against each of the first and second pistons to inject the fluid from the at least the first and second hollow needles gradually into the body tissue at a rate that is uniform over time concurrently as the at least the first and second hollow needles are advanced into said body tissue from the first desired depth to the second desired depth, and 2) halt the first and second pistons when the at least the first and second hollow needles have been inserted to the second desired depth to automatically stop injection of the fluid into the body tissue.