US 10,376,682 B2
Method of manufacturing an implantable pressure-actuated drug delivery system
Chao-Wei Hwang, Ellicott City, MD (US); Hala J. Tomey, Washington, DC (US); Jon R. Resar, Stevenson, MD (US); Robert C. Matteson, III, Ellicott City, MD (US); George L. Coles, Jr., Baltimore, MD (US); Jason J. Benkoski, Ellicott City, MD (US); and Morgana M. Trexler, Baltimore, MD (US)
Assigned to The Johns Hopkins University, Baltimore, MD (US)
Filed by The Johns Hopkins University, Baltimore, MD (US)
Filed on Oct. 11, 2016, as Appl. No. 15/290,129.
Application 15/290,129 is a division of application No. 14/179,835, filed on Feb. 13, 2014, granted, now 9,504,586.
Application 14/179,835 is a division of application No. 12/985,015, filed on Jan. 5, 2011, granted, now 8,696,740, issued on Apr. 15, 2014.
Claims priority of provisional application 61/292,339, filed on Jan. 5, 2010.
Prior Publication US 2017/0028181 A1, Feb. 2, 2017
Int. Cl. A61M 31/00 (2006.01); A61F 2/82 (2013.01); A61K 9/00 (2006.01); A61L 31/16 (2006.01); A61L 31/14 (2006.01); A61L 33/00 (2006.01); B05D 1/00 (2006.01); C23C 14/22 (2006.01)
CPC A61M 31/002 (2013.01) [A61F 2/82 (2013.01); A61K 9/0012 (2013.01); A61K 9/0024 (2013.01); A61K 9/0097 (2013.01); A61L 31/145 (2013.01); A61L 31/16 (2013.01); A61L 33/0017 (2013.01); B05D 1/005 (2013.01); C23C 14/22 (2013.01); A61F 2240/001 (2013.01); A61F 2250/0068 (2013.01); A61F 2250/0071 (2013.01); A61L 2300/42 (2013.01); A61L 2300/602 (2013.01); A61L 2300/606 (2013.01); A61L 2420/02 (2013.01); Y10T 29/49826 (2015.01)] 10 Claims
OG exemplary drawing
 
1. A method of fabricating an implantable, pressure-actuated drug delivery system, the method comprising:
fabricating a frangible layer of one or more materials over a substrate surface;
forming a cavity within the substrate, including an opening through the substrate surface to expose at least a portion of the frangible layer to the cavity;
disposing a drug within the cavity;
sealing the cavity;
pressurizing the cavity; and
fabricating a substantially non-frangible layer of an implant-environment-dissipative material over the frangible layer to prevent premature rupture of the frangible layer an at an ambient environment pressure and to dissipate within an implant environment,
wherein the frangible layer is fabricated to have a rupture threshold within a range of approximately 200 millimeters of mercury (mmHg) to 1200 mmHg, and a rupture time of at least 15 seconds, and
wherein the pressurized cavity is pressurized to a pressure that exceeds the rupture threshold by a rupture pressure within a range of approximately 20 mmHg to 50 mmHg relative to one atmosphere to cause the frangible layer to rupture when the implant environment pressure falls below and remains below the rupture pressure for at least 15 seconds.