US 10,376,630 B2
Integrated Strontium-Rubidium radioisotope infusion systems
Stephen E. Hidem, Edina, MN (US); Aaron M. Fontaine, Minneapolis, MN (US); Janet L. Gelbach, Schaumburg, IL (US); Patrick M. McDonald, Omaha, NE (US); Kathryn M. Hunter, Knoxville, TN (US); Rolf E. Swenson, Silver Spring, MD (US); and Julius P. Zodda, Mercerville, NJ (US)
Assigned to Bracco Diagnostics Inc., Monroe Township, NJ (US)
Filed by Bracco Diagnostics Inc., Monroe Township, NJ (US)
Filed on Oct. 3, 2018, as Appl. No. 16/150,702.
Application 16/150,702 is a continuation of application No. 16/114,132, filed on Aug. 27, 2018.
Application 16/114,132 is a continuation of application No. 15/809,103, filed on Nov. 10, 2017, abandoned.
Application 15/809,103 is a continuation of application No. 15/620,320, filed on Jun. 12, 2017, granted, now 9,814,826.
Application 15/620,320 is a continuation of application No. 15/389,200, filed on Dec. 22, 2016, granted, now 9,750,869.
Application 15/389,200 is a continuation of application No. 12/808,467, granted, now 9,607,722, previously published as PCT/US2009/047031, filed on Jun. 11, 2009.
Application 12/808,467 is a continuation of application No. 12/137,377, filed on Jun. 11, 2008, granted, now 8,708,352.
Application 12/137,377 is a continuation of application No. 12/137,363, filed on Jun. 11, 2008, granted, now 7,862,534.
Application 12/137,363 is a continuation of application No. 12/137,356, filed on Jun. 11, 2008, granted, now 8,317,674.
Application 12/137,356 is a continuation of application No. 12/137,364, filed on Jun. 11, 2008, granted, now 9,597,053.
Prior Publication US 2019/0060558 A1, Feb. 28, 2019
This patent is subject to a terminal disclaimer.
Int. Cl. A61N 5/10 (2006.01); A61M 5/14 (2006.01); A61M 5/142 (2006.01); G21G 4/08 (2006.01); A61M 5/00 (2006.01); A61B 90/00 (2016.01); G21F 7/00 (2006.01); G21G 1/00 (2006.01); A61B 6/00 (2006.01); A61B 6/10 (2006.01); G21F 3/00 (2006.01); A61K 51/00 (2006.01); A61B 6/03 (2006.01); A61M 5/168 (2006.01); A61B 50/13 (2016.01); A61M 5/145 (2006.01); A61M 5/158 (2006.01); G06F 21/31 (2013.01); A61M 5/36 (2006.01); G06F 19/00 (2018.01); G16H 20/17 (2018.01); A61B 50/10 (2016.01); B62B 3/00 (2006.01)
CPC A61M 5/007 (2013.01) [A61B 6/037 (2013.01); A61B 6/107 (2013.01); A61B 6/481 (2013.01); A61B 6/507 (2013.01); A61B 50/13 (2016.02); A61B 90/39 (2016.02); A61K 51/00 (2013.01); A61M 5/14 (2013.01); A61M 5/142 (2013.01); A61M 5/1452 (2013.01); A61M 5/158 (2013.01); A61M 5/16854 (2013.01); A61M 5/16881 (2013.01); A61M 5/365 (2013.01); A61N 5/1001 (2013.01); A61N 5/1007 (2013.01); A61N 5/1075 (2013.01); G06F 19/00 (2013.01); G06F 19/3468 (2013.01); G06F 21/31 (2013.01); G16H 20/17 (2018.01); G21F 3/00 (2013.01); G21F 7/00 (2013.01); G21G 1/001 (2013.01); G21G 1/0005 (2013.01); G21G 4/08 (2013.01); A61B 2050/105 (2016.02); A61B 2090/392 (2016.02); A61M 5/1409 (2013.01); A61M 2005/1403 (2013.01); A61M 2205/18 (2013.01); A61M 2205/276 (2013.01); A61M 2205/3375 (2013.01); A61M 2205/50 (2013.01); A61M 2205/505 (2013.01); A61M 2205/52 (2013.01); A61M 2205/584 (2013.01); A61M 2205/587 (2013.01); A61M 2205/6009 (2013.01); A61M 2205/6054 (2013.01); A61M 2205/6072 (2013.01); A61M 2205/70 (2013.01); A61M 2205/75 (2013.01); A61M 2209/084 (2013.01); A61N 2005/1021 (2013.01); A61N 2005/1022 (2013.01); A61N 2005/1074 (2013.01); A61N 2005/1094 (2013.01); B62B 3/005 (2013.01); G21G 2001/0031 (2013.01)] 30 Claims
OG exemplary drawing
 
1. A method of building an infusion system to deliver a rubidium radioactive eluate comprising:
installing on a cart a first shielding compartment having a first opening, a second shielding compartment having a second opening, and a shielded well, wherein:
the first opening is configured for a strontium-rubidium radioisotope generator to be inserted into and removed from the first shielding compartment,
the second opening is configured for a waste bottle to be inserted into and removed from the second shielding compartment, and
the shielded well is configured to receive an eluate reservoir, the eluate reservoir being configured to receive a sample of the rubidium radioactive eluate;
configuring a computer for the infusion system to:
collect the sample of the rubidium radioactive eluate in the eluate reservoir by pumping saline from a saline reservoir into the strontium-rubidium radioisotope generator via a saline tubing line thereby generating the rubidium radioactive eluate that is discharged through an eluate tubing line,
determine a strontium breakthrough test result on the sample of the rubidium radioactive eluate collected in the eluate reservoir in the shielded well on-board the cart while the eluate reservoir remains in the shielded well on-board the cart,
not allow a patient infusion if the strontium breakthrough test result is greater than or equal to an allowed limit,
track a volume of saline in the saline reservoir,
not allow a patient infusion if the volume of saline in the saline reservoir is below a predetermined saline threshold,
track a volume of a waste in the waste bottle, and
not allow a patient infusion if the volume of waste in the waste bottle is above a predetermined waste threshold.