US 10,376,611 B2
Multilayered bone graft and method of making same
Francois Barthelat, Montreal (CA); Michael Tanzer, Hampstead (CA); and Sacha Cavelier, Montreal (CA)
Assigned to THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, Montreal (CA)
Filed by THE ROYAL INSTITUTION FOR THE ADVANCEMENT OF LEARNING/MCGILL UNIVERSITY, Montreal (CA)
Filed on Feb. 16, 2016, as Appl. No. 15/44,414.
Claims priority of provisional application 62/116,612, filed on Feb. 16, 2015.
Prior Publication US 2016/0235536 A1, Aug. 18, 2016
Int. Cl. A61F 2/28 (2006.01); A61L 27/12 (2006.01); B29C 67/24 (2006.01); A61L 27/24 (2006.01); A61L 27/22 (2006.01); B29C 33/38 (2006.01); B33Y 80/00 (2015.01); B33Y 10/00 (2015.01); B29L 31/00 (2006.01); A61F 2/30 (2006.01)
CPC A61L 27/12 (2013.01) [A61F 2/28 (2013.01); A61F 2/2875 (2013.01); A61L 27/222 (2013.01); A61L 27/24 (2013.01); B29C 33/3835 (2013.01); B29C 67/24 (2013.01); B33Y 10/00 (2014.12); B33Y 80/00 (2014.12); A61F 2002/30014 (2013.01); A61F 2002/30293 (2013.01); A61F 2002/30948 (2013.01); A61F 2002/30957 (2013.01); A61F 2002/30962 (2013.01); A61F 2002/30971 (2013.01); A61F 2210/0076 (2013.01); A61F 2310/00293 (2013.01); A61F 2310/00359 (2013.01); A61L 2430/02 (2013.01); B29K 2089/00 (2013.01); B29K 2995/0082 (2013.01); B29L 2031/7532 (2013.01)] 14 Claims
OG exemplary drawing
 
1. A synthetic bone graft adapted to be received within a bone defect, the bone graft comprising an entirely synthetic graft body corresponding in shape and size to the bone defect and being structurally load-bearing, the graft body being composed of a plurality of superimposed multilayered structures, each of said multilayered structures having a biopolymer layer joined to a biomineral layer to define an interface therebetween, wherein the biomineral layer has a stiffness that is at least five times greater than that of the biopolymer layer, and the biopolymer layer has a toughness that is at least four times less than that of the biomineral layer.