US 10,376,602 B2
Methods for diagnosing and monitoring eosinophilic esophagitis
Leonard F. Pease, Bountiful, UT (US); Hedieh Saffari, Salt Lake City, UT (US); Gerald J. Gleich, Salt Lake City, UT (US); Kristin M. Leiferman, Salt Lake City, UT (US); Kathryn A. Peterson, Salt Lake City, UT (US); and Russell Morris Condie, Salt Lake City, UT (US)
Assigned to UNIVERSITY OF UTAH RESEARCH FOUNDATION, , UT (US)
Filed by University of Utah Research Foundation, Salt lake City, UT (US)
Filed on Sep. 29, 2017, as Appl. No. 15/719,827.
Application 15/719,827 is a continuation of application No. 14/402,070, granted, now 9,789,212, previously published as PCT/US2013/041595, filed on May 17, 2013.
Claims priority of provisional application 61/786,909, filed on Mar. 15, 2013.
Claims priority of provisional application 61/688,650, filed on May 18, 2012.
Prior Publication US 2018/0036440 A1, Feb. 8, 2018
Int. Cl. A61K 49/00 (2006.01); A61K 51/04 (2006.01); A61K 51/08 (2006.01)
CPC A61K 51/0491 (2013.01) [A61K 51/08 (2013.01)] 32 Claims
 
1. A method of producing a medical image of an organ, wherein the organ is an ovary, a breast, a brain, a muscle, a heart, a lung, a stomach, a proximal large intestine, a distal large intestine, a small intestine, a pancreas, a thyroid, skin, an eye, a testicle, a thymus, a gallbladder or a uterus in a subject, said method comprising:
administering to a subject radiolabeled heparin wherein the radiolabeled heparin binds to one or more eosinophil granule proteins in the tissue of the subject's ovary, breast, brain, muscle, heart, lung, stomach, proximal large intestine, distal large intestine, small intestine, pancreas, thyroid, skin, eye, testicle, thymus, gallbladder or uterus, wherein said binding generates a radiolabeled heparin eosinophil granule protein complex, wherein the eosinophil granule protein is major basic protein 1 (MBP-1), major basic protein 2 (MBP-2), eosinophil derived neurotoxin (EDN), eosinophil cationic protein (ECP), or eosinophil peroxidase (EPO), and
detecting the radiolabeled heparin eosinophil granule protein complex in the tissue of the subject's ovary, breast, brain, muscle, heart, lung, stomach, proximal large intestine, distal large intestine, small intestine, pancreas, thyroid, skin, eye, testicle, thymus, gallbladder or uterus,
whereby detecting the radiolabeled heparin eosinophil granule protein complex in the tissue of the subject's ovary, breast, brain, muscle, heart, lung, stomach, intestines, pancreas, thyroid, skin, eye, testicle, thymus, gallbladder or uterus produces a medical image of the ovary, the breast, the brain, the muscle, the heart, the lung, the stomach, the proximal large intestine, the distal large intestine, the small intestine, the pancreas, the thyroid, the skin, the eye, the testicle, the thymus, the gallbladder the or uterus in the subject.