US 10,376,596 B2
Antimicrobial compositions comprising single domain antibodies and pseudomonas exotoxin
Richard Markham, Columbia, MD (US); and Eileen Geoghegan, Baltimore, MD (US)
Assigned to The Johns Hopkins University, Baltimore, MD (US)
Filed by THE JOHNS HOPKINS UNIVERSITY, Baltimore, MD (US)
Filed on Jun. 13, 2018, as Appl. No. 16/7,052.
Application 16/007,052 is a division of application No. 15/108,380, granted, now 10,010,625, previously published as PCT/US2015/010045, filed on Jan. 2, 2015.
Claims priority of provisional application 61/922,927, filed on Jan. 2, 2014.
Prior Publication US 2018/0289833 A1, Oct. 11, 2018
Int. Cl. A61K 39/00 (2006.01); A61K 47/68 (2017.01); C07K 14/21 (2006.01); C07K 16/08 (2006.01)
CPC A61K 47/6839 (2017.08) [A61K 47/6813 (2017.08); A61K 47/6829 (2017.08); C07K 14/21 (2013.01); C07K 16/087 (2013.01); A61K 2039/505 (2013.01); A61K 2039/70 (2013.01); C07K 2317/35 (2013.01); C07K 2317/51 (2013.01); C07K 2317/569 (2013.01); C07K 2317/76 (2013.01); C07K 2319/55 (2013.01)] 12 Claims
 
1. A heavy chain immunoglobulin of the VHH type or fragment thereof, wherein the heavy chain immunoglobulin of the VHH type or fragment thereof comprises an amino acid sequence of at least 90% identity to SEQ ID NO: 3.