US 10,376,591 B2
Formulations and carrier systems including farnesylthiosalicylic moieties
Song Li, Wexford, PA (US); Yixian Huang, Pittsburgh, PA (US); Xiaolan Zhang, Foster City, CA (US); and Xiang Gao, Pittsburgh, PA (US)
Assigned to University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Filed by University of Pittsburgh—Of the Commonwealth System of Higher Education, Pittsburgh, PA (US)
Filed on Sep. 13, 2017, as Appl. No. 15/703,110.
Application 15/703,110 is a continuation of application No. 14/625,873, filed on Feb. 19, 2015, granted, now 9,855,341.
Claims priority of provisional application 61/941,998, filed on Feb. 19, 2014.
Prior Publication US 2018/0000957 A1, Jan. 4, 2018
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 47/60 (2017.01); A61K 31/337 (2006.01); A61K 31/235 (2006.01); A61K 31/704 (2006.01); A61K 9/00 (2006.01); A61K 9/107 (2006.01); C08G 65/331 (2006.01); C08G 65/333 (2006.01); C08G 65/334 (2006.01)
CPC A61K 47/60 (2017.08) [A61K 9/0019 (2013.01); A61K 9/1075 (2013.01); A61K 31/235 (2013.01); A61K 31/337 (2013.01); A61K 31/704 (2013.01); C08G 65/331 (2013.01); C08G 65/334 (2013.01); C08G 65/3311 (2013.01); C08G 65/3344 (2013.01); C08G 65/33306 (2013.01); C08G 65/33396 (2013.01); C08L 2203/02 (2013.01)] 19 Claims
 
1. A method of forming a formulation, comprising:
forming a carrier agent by conjugating at least one biologically active hydrophobic compound with at least one hydrophilic oligomer or at least one hydrophilic polymer, the at least one biologically active hydrophobic compound selected from the group of farnesylthiosalicylic acid and a derivative of farnesylthiosalicylic acid which is biologically active as an RAS antagonist, wherein a plurality of the carrier agents are adapted to assemble into a structure and the at least one biologically active hydrophobic compound is conjugated with the at least one hydrophilic oligomer or at least one hydrophilic polymer via a linkage which is labile in vivo, and
associating a biologically active compound with the carrier agent.