US 10,376,587 B2
High capacity diketopiperazine microparticles and methods
Marshall Grant, Newtown, CT (US); Paul Menkin, Branford, CT (US); and Grayson W. Stowell, Cary, NC (US)
Assigned to MannKind Corporation, Valencia, CA (US)
Filed by MannKind Corporation, Westlake Village, CA (US)
Filed on Oct. 4, 2018, as Appl. No. 16/151,678.
Application 16/151,678 is a division of application No. 15/152,355, filed on May 11, 2016, granted, now 10,130,709.
Application 15/152,355 is a division of application No. 14/127,158, granted, now 9,364,436, previously published as PCT/US2012/042998, filed on Jun. 18, 2012.
Claims priority of provisional application 61/498,476, filed on Jun. 17, 2011.
Prior Publication US 2019/0076530 A1, Mar. 14, 2019
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 31/495 (2006.01); A61K 47/22 (2006.01); A61K 9/00 (2006.01); A61K 9/14 (2006.01); A61K 38/28 (2006.01); A61K 9/50 (2006.01)
CPC A61K 47/22 (2013.01) [A61K 9/0075 (2013.01); A61K 9/14 (2013.01); A61K 9/50 (2013.01); A61K 38/28 (2013.01); Y10T 428/2982 (2015.01)] 14 Claims
1. A method of delivering a drug or an active agent to a patient in need thereof comprising administering to the patient in need thereof using a reusable inhaler an inhalable composition comprising a drug or active agent and diketopiperazine microparticles, each of the diketopiperazine microparticles comprising a plurality of structural domains, each of the plurality of structural domains comprising a nucleus surrounded by layers of a porous crystalline material, and each of the diketopiperazine microparticles have a mass-weighted average particle size of about 33,000 to about 216,000 voxels measured by X-ray tomography for particle sizes measuring from about 0.5 pm to about 4 pm in geometric diameter.