US 10,376,585 B2
Injectable antibiotic formulations and their methods of use
Fadil Al Alawi, Auckland (NZ); Olaf Bork, Hamilton (NZ); Rohit Jain, Hamilton (NZ); Karthigeyan Nanjan, Hamilton (NZ); and Ian George Tucker, Hamilton (NZ)
Assigned to BAYER NEW ZEALAND LTD, Hamilton (NZ)
Appl. No. 14/415,940
Filed by BAYER NEW ZEALAND LTD, Hamilton (NZ)
PCT Filed Jul. 16, 2013, PCT No. PCT/NZ2013/000123
§ 371(c)(1), (2) Date Jan. 20, 2015,
PCT Pub. No. WO2014/014363, PCT Pub. Date Jan. 23, 2014.
Claims priority of application No. 601299 (NZ), filed on Jul. 17, 2012; application No. 610175 (NZ), filed on May 3, 2013; and application No. 613138 (NZ), filed on Jul. 12, 2013.
Prior Publication US 2015/0174248 A1, Jun. 25, 2015
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 47/14 (2017.01); A61K 9/00 (2006.01); A61K 47/10 (2017.01); A61K 47/24 (2006.01); A61K 31/43 (2006.01); A61K 47/26 (2006.01); A61K 9/10 (2006.01); A61K 47/44 (2017.01)
CPC A61K 47/14 (2013.01) [A61K 9/0019 (2013.01); A61K 9/10 (2013.01); A61K 31/43 (2013.01); A61K 47/10 (2013.01); A61K 47/24 (2013.01); A61K 47/26 (2013.01); A61K 47/44 (2013.01)] 26 Claims
 
1. An injectable, ready-to-use, oil-based, non-aqueous veterinary pharmaceutical composition comprising as the only antibiotic in the composition, penethamate (PNT) hydroiodide, and at least one oily vehicle selected from one or more of the group consisting of ethyl oleate, medium chain triglycerides, and triacetin, wherein the ratio of the PNT hydroiodide to the at least one oily vehicle is 1:1 to 1:4 w/v, wherein the concentration of PNT hydroiodide is between 15-55% w/v, and wherein the viscosity of the composition is below 3000 mPas at a temperature of 20° C. and a shear rate of 1/s when measured with a cup cylinder method, and wherein the penethamate hydroiodide shows substantially no degradation after storage of the composition over 180 days at 30 degrees Celsius.