US 10,376,581 B2
Human endothelin receptor antibody and use thereof
Cheng Zhang, Hangzhou (CN); Hua Zhang, Hangzhou (CN); Xiaofeng Wang, Hangzhou (CN); Chenjiang Yao, Hangzhou (CN); Yan Jiang, Hangzhou (CN); Min Wang, Hangzhou (CN); Xinxin Shi, Hangzhou (CN); Hao Pan, Hangzhou (CN); and Shuqian Jing, Hangzhou (CN)
Assigned to Gmax Biopharm LLC., Hangzhou (CN)
Appl. No. 15/537,190
Filed by Gmax Biopharm LLC., Hangzhou (CN)
PCT Filed Jul. 22, 2016, PCT No. PCT/CN2016/090960
§ 371(c)(1), (2) Date Jun. 16, 2017,
PCT Pub. No. WO2017/092375, PCT Pub. Date Jun. 8, 2017.
Claims priority of application No. 2015 1 0867288 (CN), filed on Dec. 1, 2015.
Prior Publication US 2018/0256714 A1, Sep. 13, 2018
Int. Cl. A61K 39/395 (2006.01); C07K 16/18 (2006.01); C07K 16/28 (2006.01); C12N 5/10 (2006.01); C12N 5/12 (2006.01); C12N 15/63 (2006.01); C07K 16/26 (2006.01); A61P 9/00 (2006.01); A61P 35/00 (2006.01); A61K 39/00 (2006.01)
CPC A61K 39/39558 (2013.01) [C07K 16/26 (2013.01); C07K 16/28 (2013.01); C12N 5/10 (2013.01); C12N 5/12 (2013.01); C12N 15/63 (2013.01); A61K 2039/505 (2013.01); A61P 9/00 (2018.01); A61P 35/00 (2018.01); C07K 2317/24 (2013.01); C07K 2317/30 (2013.01); C07K 2317/565 (2013.01); C07K 2317/70 (2013.01); C07K 2317/76 (2013.01); C07K 2317/92 (2013.01)] 10 Claims
 
1. An antibody that specifically binds to a human endothelin receptor, comprising:
light chain CDR1 amino acid sequence: SEQ ID NO: 8;
light chain CDR2 amino acid sequence: SEQ ID NO: 32;
light chain CDR3 amino acid sequence: SEQ ID NO: 50;
heavy chain CDR1 amino acid sequence: SEQ ID NO: 70;
heavy chain CDR2 amino acid sequence: SEQ ID NO: 92; and
heavy chain CDR3 amino acid sequence: SEQ ID NO: 116.