US 10,376,577 B2
Refined product obtained from rice hull and preparation process and use thereof
Wen-Chuan Lin, Taichung (TW); Li-Chan Yang, Taichung (TW); and Chang-Chi Hsieh, Taichung (TW)
Assigned to China Medical University, Taichung (TW)
Filed by China Medical University, Taichung (TW)
Filed on Aug. 20, 2015, as Appl. No. 14/831,275.
Claims priority of application No. 103129334 A (TW), filed on Aug. 26, 2014.
Prior Publication US 2016/0060367 A1, Mar. 3, 2016
Int. Cl. A61K 36/899 (2006.01); A61K 39/39 (2006.01); A61K 31/715 (2006.01); C12P 19/14 (2006.01); C12P 19/04 (2006.01); C08B 37/00 (2006.01); A61K 39/00 (2006.01)
CPC A61K 39/39 (2013.01) [A61K 31/715 (2013.01); A61K 36/899 (2013.01); C08B 37/0003 (2013.01); C08B 37/006 (2013.01); C12P 19/04 (2013.01); C12P 19/14 (2013.01); A61K 2039/55583 (2013.01)] 4 Claims
1. A process for producing a refined product from a rice hull, comprising:
subjecting a rice hull to extraction with an aqueous solution so as to obtain an aqueous extract;
admixing the aqueous extract with a first alcohol so as to obtain a first precipitate;
subjecting the first precipitate to an enzymatic hydrolysis treatment so as to obtain an aqueous enzymatic hydrolysate, the enzymatic hydrolysis treatment employing an aqueous composition containing α-amylase, protease, and amyloglucosidase;
admixing the aqueous enzymatic hydrolysate with a second alcohol so as to obtain a second precipitate; and
refining the second precipitate by anion exchange chromatography, such that the refined product thus obtained consists essentially of a type II arabinogalactan having a number average molecular weight in the range of 56 to 103 kDa.