US 10,376,567 B2
Fusion molecule based on TAA variant
Zhenhua Li, Los Angeles, CA (US); and Arie S. Belldegrun, Los Angeles, CA (US)
Assigned to The Regents of the University of California, Oakland, CA (US)
Filed by The Regents of the University of California, Oakland, CA (US)
Filed on Apr. 6, 2018, as Appl. No. 15/947,469.
Application 15/947,469 is a division of application No. 15/293,710, filed on Oct. 14, 2016, granted, now 9,968,664.
Application 15/073,162 is a division of application No. 13/740,099, filed on Jan. 11, 2013, granted, now 9,322,010, issued on Apr. 26, 2016.
Application 15/293,710 is a continuation of application No. 15/073,162, filed on Mar. 17, 2016, granted, now 9,492,520, issued on Nov. 15, 2016.
Application 13/740,099 is a continuation of application No. 12/520,084, granted, now 8,378,084, issued on Feb. 19, 2013, previously published as PCT/US2007/088676, filed on Dec. 21, 2007.
Claims priority of provisional application 60/876,863, filed on Dec. 22, 2006.
Prior Publication US 2018/0228882 A1, Aug. 16, 2018
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 39/00 (2006.01); C12N 15/62 (2006.01); C12N 15/63 (2006.01); A61K 38/19 (2006.01); C12N 5/078 (2010.01); C07K 14/535 (2006.01); C12N 9/88 (2006.01); G01N 33/574 (2006.01); C12N 9/96 (2006.01); A61K 45/06 (2006.01)
CPC A61K 39/0011 (2013.01) [A61K 38/193 (2013.01); C07K 14/535 (2013.01); C12N 5/0634 (2013.01); C12N 9/88 (2013.01); C12N 15/62 (2013.01); C12N 15/63 (2013.01); C12Y 402/01001 (2013.01); A61K 45/06 (2013.01); A61K 2039/5154 (2013.01); A61K 2039/5156 (2013.01); A61K 2039/5158 (2013.01); A61K 2039/55522 (2013.01); C07K 2319/75 (2013.01); C12N 9/96 (2013.01); C12N 2501/22 (2013.01); C12N 2501/2302 (2013.01); C12N 2501/24 (2013.01); C12N 2501/70 (2013.01); G01N 33/57411 (2013.01); G01N 33/57438 (2013.01); G01N 2333/988 (2013.01)] 20 Claims
 
1. A vector gene delivery system, comprising a vector that comprises a nucleic acid encoding a fusion protein comprising a portion of carbonic anhydrase IX (CAIX) variant protein (SEQ ID NO:1) attached to a granulocyte macrophage colony stimulating factor (GM-CSF), wherein the portion of the CAIX variant protein comprises the amino acids G121 and S374.