US 10,376,566 B2
Composition and method for improving sleep duration and quality
Jack N. Losso, Baton Rouge, LA (US); and Jose Daniel Estrada Andino, Baton Rouge, LA (US)
Assigned to Board of Supervisors of Louisiana State University and Agricultural and Mechanical College, Baton Rouge, LA (US)
Filed by Jack N. Losso, Baton Rouge, LA (US); and Jose Daniel Estrada Andino, Baton Rouge, LA (US)
Filed on Jun. 16, 2017, as Appl. No. 15/625,777.
Claims priority of provisional application 62/364,474, filed on Jul. 20, 2016.
Prior Publication US 2018/0021411 A1, Jan. 25, 2018
Int. Cl. A61K 38/00 (2006.01); A61K 38/39 (2006.01); A61K 31/198 (2006.01); A61K 31/728 (2006.01); A61K 31/353 (2006.01); A61K 31/191 (2006.01); A61K 31/343 (2006.01); A61K 36/28 (2006.01); A61K 31/28 (2006.01); A61K 31/365 (2006.01)
CPC A61K 38/39 (2013.01) [A61K 31/191 (2013.01); A61K 31/198 (2013.01); A61K 31/28 (2013.01); A61K 31/343 (2013.01); A61K 31/353 (2013.01); A61K 31/365 (2013.01); A61K 31/728 (2013.01); A61K 36/28 (2013.01)] 5 Claims
 
1. A composition comprising:
(a) a first component selected from one or more of the following: collagen, a gelatin peptide, or the amino acid glycine; wherein said first component has a molecular weight less than 3500 Dalton;
(b) a second component comprising L-theanine;
(c) a third component comprising lactucopicrin, deoxylactucopicrin, or another lactucopicrin derivative;
(d) a fourth component comprising hyaluronic acid;
(e) a fifth component comprising epigallocatechin gallate; and
(f) a sixth component comprising quinic acid;
wherein:
said composition is supplied in aqueous solution or aqueous suspension, or said composition is supplied as a powder that can be reconstituted into an aqueous solution or an aqueous suspension; wherein the concentrations of the components of the aqueous solution or aqueous suspension are such that 30-60 mL of the aqueous solution or aqueous suspension supplies one dose that comprises: (i) 0.5 to 12 g collagen peptide, or 0.5 to 5 g glycine as amino acid; i.e., all or part of said first component; (ii) a tea (Camellia sinensis) extract containing 100 to 500 mg theanine, and 50 to 300 mg epigallocatechin gallate; i.e., all or part of said second and fifth components; and (iii) 1 to 10 g chicory (Cichorium intybus) extract containing lactucopicrin, deoxylactucopicrin, or another lactucopicrin; i.e., all or part of said third component;
and wherein:
said composition has the property that, if one dose of said composition is consumed orally by a human, one or more of the following will be improved: onset of sleep, sleep depth, sleep quality, sleep duration, sleep apnea, or fatigue during the waking part of the day.