US 10,376,562 B2
Methods for promoting wound healing and hair growth comprising GDNF administration
Robert E. Braun, Bar Harbor, ME (US); and Manju Sharma, Bar Harbor, ME (US)
Assigned to The Jackson Laboratory, Bar Harbor, ME (US)
Appl. No. 14/775,386
Filed by The Jackson Laboratory, Bar Harbor, ME (US)
PCT Filed Mar. 14, 2014, PCT No. PCT/US2014/027419
§ 371(c)(1), (2) Date Sep. 11, 2015,
PCT Pub. No. WO2014/152511, PCT Pub. Date Sep. 25, 2014.
Claims priority of provisional application 61/787,870, filed on Mar. 15, 2013.
Prior Publication US 2016/0022773 A1, Jan. 28, 2016
Int. Cl. A61K 8/64 (2006.01); A61K 38/18 (2006.01); A61Q 7/00 (2006.01); C07K 14/475 (2006.01)
CPC A61K 38/185 (2013.01) [A61K 8/64 (2013.01); A61Q 7/00 (2013.01); C07K 14/4756 (2013.01)] 13 Claims
1. A method for promoting hair growth on a subject, the method comprising the steps of: (a) administering at a site of desired hair growth on said subject a composition comprising a pharmaceutically effective dose of an isolated glial cell derived neurotrophic factor (GDNF), wherein said GDNF consists of residues 78-211 of SEQ ID NO:7 or residues 118-211 of SEQ ID NO:7; and (b) repeating said administrating step for a time period sufficient to promote said hair growth on said subject.