US 10,376,561 B1
Fasciola hepatica fatty acid binding protein a novel anti-inflammatory molecule
Ana M. Espino, San Juan, PR (US); and Ivelisse Martin, San Juan, PR (US)
Assigned to University of Puerto Rico, San Juan, PR (US)
Filed by Ana M. Espino, San Juan, PR (US); and Ivelisse Martin, San Juan, PR (US)
Filed on May 16, 2016, as Appl. No. 15/156,284.
Claims priority of provisional application 62/161,582, filed on May 14, 2015.
Int. Cl. A61K 38/16 (2006.01)
CPC A61K 38/16 (2013.01) 11 Claims
 
1. A method of reducing TLR4-mediated inflammation on a mammal comprising: administering to said mammal an amount of Fasciola hepatica fatty acid binding protein (Fh12) that specifically binds to a CD14 co-receptor of a TLR4 protein of antigen-presenting cells effectively reducing activation of TLR4 and the inflammatory response on said mammal.