US 10,376,556 B2
Methods and compositions for modulating transport of a drug
Jeffrey D. Laskin, Piscataway, NJ (US); Ron Udasin, East Brunswick, NJ (US); and Lauren Aleksunes, Bridgewater, NJ (US)
Filed by Jeffrey D. Laskin, Piscataway, NJ (US); Ron Udasin, East Brunswick, NJ (US); and Lauren Aleksunes, Bridgewater, NJ (US)
Filed on Dec. 18, 2017, as Appl. No. 15/845,017.
Application 15/845,017 is a continuation of application No. 15/270,439, filed on Sep. 20, 2016, granted, now 9,849,155.
Prior Publication US 2018/0104302 A1, Apr. 19, 2018
Int. Cl. A61K 38/03 (2006.01); A61K 38/06 (2006.01); A61K 38/05 (2006.01); C07K 5/02 (2006.01)
CPC A61K 38/05 (2013.01) [A61K 38/03 (2013.01); A61K 38/063 (2013.01); C07K 5/0215 (2013.01)] 13 Claims
 
1. A method for inhibiting or decreasing transport of a drug by a transporter of multidrug resistance-associated protein in a cell, said method comprising administering to the cell a compound of Formula (IV)

OG Complex Work Unit Drawing
wherein R1 and R2 are small peptides or modified peptides; and wherein the cell is a microbe.