US 10,376,555 B2
Identification of cyclic peptide agonists of galanin receptor 2 and 3 guided by spexin solution structure
Zhaoxiang Bian, Hong Kong (HK); Tao Huang, Hong Kong (HK); and Chengyuan Lin, Hong Kong (HK)
Assigned to Hong Kong Baptist University, Hong Kong (HK)
Filed by Hong Kong Baptist University, Hong Kong (HK)
Filed on Mar. 20, 2018, as Appl. No. 15/925,949.
Claims priority of provisional application 62/482,751, filed on Apr. 7, 2017.
Claims priority of provisional application 62/506,654, filed on May 16, 2017.
Prior Publication US 2018/0289766 A1, Oct. 11, 2018
Int. Cl. C07K 5/12 (2006.01); C07K 7/08 (2006.01); A61K 38/10 (2006.01); A61K 38/12 (2006.01); A61K 38/02 (2006.01); A61K 38/22 (2006.01); A61K 38/00 (2006.01); A61K 38/17 (2006.01); A61K 9/00 (2006.01); A61P 3/04 (2006.01)
CPC A61K 38/02 (2013.01) [A61K 9/0019 (2013.01); A61K 38/005 (2013.01); A61K 38/1796 (2013.01); A61K 38/22 (2013.01); A61P 3/04 (2018.01)] 19 Claims
 
1. A peptide comprising a sequence having at least 92.8% homology with SEQ ID NO: 23 or SEQ ID NO: 24; or having at least 93.7% homology with SEQ ID NO: 25 or a therapeutically effective salt thereof, wherein R1 is hydrogen, alkyl, or acyl with the proviso that SEQ ID NO: 23 must contain cysteine at position one and position thirteen of SEQ ID NO: 23; SEQ ID NO: 24 must contain cysteine at position four and position thirteen of SEQ ID NO: 24; and SEQ ID NO: 25 must contain cysteines at position one and position thirteen of SEQ ID NO: 25.