US 10,376,545 B2
Methods for producing hormone secreting cells in a subject
Alan D. Agulnick, San Diego, CA (US); and Kevin Allen D'Amour, San Diego, CA (US)
Assigned to ViaCyte, Inc., San Diego, CA (US)
Filed by ViaCyte, Inc., San Diego, CA (US)
Filed on Apr. 3, 2017, as Appl. No. 15/478,094.
Application 15/478,094 is a continuation of application No. 14/455,059, filed on Aug. 8, 2014, granted, now 9,650,610, issued on May 16, 2017.
Application 14/455,059 is a continuation of application No. 14/106,330, filed on Dec. 13, 2013, granted, now 8,859,286, issued on Oct. 14, 2014.
Claims priority of provisional application 61/781,005, filed on Mar. 14, 2013.
Prior Publication US 2017/0202885 A1, Jul. 20, 2017
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 35/39 (2015.01); C12N 5/071 (2010.01); A61K 35/545 (2015.01); G01N 33/68 (2006.01)
CPC A61K 35/39 (2013.01) [A61K 35/545 (2013.01); C12N 5/0676 (2013.01); C12N 5/0678 (2013.01); C12N 2500/25 (2013.01); C12N 2501/115 (2013.01); C12N 2501/117 (2013.01); C12N 2501/119 (2013.01); C12N 2501/15 (2013.01); C12N 2501/155 (2013.01); C12N 2501/16 (2013.01); C12N 2501/195 (2013.01); C12N 2501/385 (2013.01); C12N 2501/415 (2013.01); C12N 2501/727 (2013.01); C12N 2501/998 (2013.01); C12N 2501/999 (2013.01); C12N 2506/02 (2013.01); C12N 2506/45 (2013.01); C12N 2533/90 (2013.01)] 18 Claims
 
1. A method for producing hormone secreting cells, said method comprising:
maturing transplanted endocrine cells in vivo in a subject wherein the endocrine cells co-express INS+ and NKX6.1+, thereby producing hormone secreting cells.