US 10,376,539 B2
Augmentation of antiinflammatory, immunomodulatory, and regenerative processes in amyotrophic lateral sclerosis using xenon and noble gas combinations
Vlad Bogin, Portland, OR (US); Thomas Ichim, San Diego, CA (US); and Santosh Kesari, Santa Monica, CA (US)
Assigned to Nobilis Therapeutics, Inc., Portland, OR (US)
Filed on May 17, 2017, as Appl. No. 15/598,268.
Claims priority of provisional application 62/337,787, filed on May 17, 2016.
Prior Publication US 2017/0333473 A1, Nov. 23, 2017
Int. Cl. A61K 35/28 (2015.01); A61K 33/00 (2006.01); A61K 35/51 (2015.01); A61K 35/12 (2015.01)
CPC A61K 33/00 (2013.01) [A61K 35/28 (2013.01); A61K 35/51 (2013.01); A61K 2035/124 (2013.01)] 7 Claims
OG exemplary drawing
1. A method of ameliorating a neurological condition in a subject in need thereof, wherein the neurological condition is amyotrophic lateral sclerosis (ALS), comprising the steps of:
a) identifying a subject suffering from the neurological condition;
b) performing an intervention by administering a therapeutically effective amount of bone marrow mononuclear stem cells (BMMCs) that stimulate endogenous regenerative cells in said subject; and
c) administrating a gas composition comprising a therapeutically effective concentration of a xenon gas with sufficient frequency to improve the effect of said BMMCs that stimulate said endogenous regenerative cells.