US 10,376,539 B2
Augmentation of antiinflammatory, immunomodulatory, and regenerative processes in amyotrophic lateral sclerosis using xenon and noble gas combinations
Vlad Bogin, Portland, OR (US); Thomas Ichim, San Diego, CA (US); and Santosh Kesari, Santa Monica, CA (US)
Assigned to Nobilis Therapeutics, Inc., Portland, OR (US)
Filed by NOBLIS THERAPEUTICS, INC., Portland, OR (US)
Filed on May 17, 2017, as Appl. No. 15/598,268.
Claims priority of provisional application 62/337,787, filed on May 17, 2016.
Prior Publication US 2017/0333473 A1, Nov. 23, 2017
Int. Cl. A61K 35/28 (2015.01); A61K 33/00 (2006.01); A61K 35/51 (2015.01); A61K 35/12 (2015.01)
CPC A61K 33/00 (2013.01) [A61K 35/28 (2013.01); A61K 35/51 (2013.01); A61K 2035/124 (2013.01)] 7 Claims
OG exemplary drawing
 
1. A method of ameliorating a neurological condition in a subject in need thereof, wherein the neurological condition is amyotrophic lateral sclerosis (ALS), comprising the steps of:
a) identifying a subject suffering from the neurological condition;
b) performing an intervention by administering a therapeutically effective amount of bone marrow mononuclear stem cells (BMMCs) that stimulate endogenous regenerative cells in said subject; and
c) administrating a gas composition comprising a therapeutically effective concentration of a xenon gas with sufficient frequency to improve the effect of said BMMCs that stimulate said endogenous regenerative cells.