| US 10,376,538 B2 | ||
| Topical gels and methods of using the same | ||
| Nathan Stasko, Chapel Hill, NC (US); Susanne Bauman, Durham, NC (US); and Pranav R. Joshi, Electronic City West (IN) | ||
| Assigned to Novan, Inc., Morrisville, NC (US) | ||
| Filed by Novan, Inc., Morrisville, NC (US) | ||
| Filed on Jul. 18, 2017, as Appl. No. 15/652,824. | ||
| Application 15/652,824 is a continuation of application No. 15/353,301, filed on Nov. 16, 2016, granted, now 9,737,561. | ||
| Application 15/353,301 is a continuation of application No. 13/256,928, granted, now 9,526,738, previously published as PCT/US2010/046173, filed on Aug. 20, 2010. | ||
| Claims priority of provisional application 61/235,933, filed on Aug. 21, 2009. | ||
| Prior Publication US 2017/0312307 A1, Nov. 2, 2017 | ||
| This patent is subject to a terminal disclaimer. | ||
| Int. Cl. A61K 9/14 (2006.01); A61K 31/80 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 31/655 (2006.01); A61K 33/00 (2006.01); A61K 47/24 (2006.01); A61K 47/59 (2017.01); A61K 47/69 (2017.01) | ||
| CPC A61K 31/80 (2013.01) [A61K 9/0014 (2013.01); A61K 9/06 (2013.01); A61K 31/655 (2013.01); A61K 33/00 (2013.01); A61K 47/24 (2013.01); A61K 47/59 (2017.08); A61K 47/6903 (2017.08)] | 33 Claims |
| 1. A topical composition comprising: nitric oxide-releasing polysiloxane macromolecules, wherein the nitric oxide-releasing polysiloxane macromolecules comprise a co-condensation of at least one aminoalkoxysilane and an alkoxysilane, and
a hydrophobic, non-aqueous gel base comprising mineral oil,
wherein the nitric oxide-releasing polysiloxane macromolecules are present in the hydrophobic, non-aqueous gel base and at least 70% of nitric oxide (NO) of the nitric oxide-releasing polysiloxane macromolecules remains in the topical composition two days after initial formulation of the topical composition, when the topical composition is stored at room temperature.
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