US 10,376,538 B2
Topical gels and methods of using the same
Nathan Stasko, Chapel Hill, NC (US); Susanne Bauman, Durham, NC (US); and Pranav R. Joshi, Electronic City West (IN)
Assigned to Novan, Inc., Morrisville, NC (US)
Filed by Novan, Inc., Morrisville, NC (US)
Filed on Jul. 18, 2017, as Appl. No. 15/652,824.
Application 15/652,824 is a continuation of application No. 15/353,301, filed on Nov. 16, 2016, granted, now 9,737,561.
Application 15/353,301 is a continuation of application No. 13/256,928, granted, now 9,526,738, previously published as PCT/US2010/046173, filed on Aug. 20, 2010.
Claims priority of provisional application 61/235,933, filed on Aug. 21, 2009.
Prior Publication US 2017/0312307 A1, Nov. 2, 2017
This patent is subject to a terminal disclaimer.
Int. Cl. A61K 9/14 (2006.01); A61K 31/80 (2006.01); A61K 9/00 (2006.01); A61K 9/06 (2006.01); A61K 31/655 (2006.01); A61K 33/00 (2006.01); A61K 47/24 (2006.01); A61K 47/59 (2017.01); A61K 47/69 (2017.01)
CPC A61K 31/80 (2013.01) [A61K 9/0014 (2013.01); A61K 9/06 (2013.01); A61K 31/655 (2013.01); A61K 33/00 (2013.01); A61K 47/24 (2013.01); A61K 47/59 (2017.08); A61K 47/6903 (2017.08)] 33 Claims
 
1. A topical composition comprising:
nitric oxide-releasing polysiloxane macromolecules, wherein the nitric oxide-releasing polysiloxane macromolecules comprise a co-condensation of at least one aminoalkoxysilane and an alkoxysilane, and
a hydrophobic, non-aqueous gel base comprising mineral oil,
wherein the nitric oxide-releasing polysiloxane macromolecules are present in the hydrophobic, non-aqueous gel base and at least 70% of nitric oxide (NO) of the nitric oxide-releasing polysiloxane macromolecules remains in the topical composition two days after initial formulation of the topical composition, when the topical composition is stored at room temperature.