US 10,376,529 B2
Combination of pentacyclic triterpenes and hydroxytyrosol and derivatives thereof
José Carlos Quintela Fernández, Madrid (ES); Esther De La Fuente García, Madrid (ES); Marco Pugliese, Sant Pere de Ribes (ES); Pilar Mancera Aroca, Roda de Barà (ES); Javier Bustos Santafé, Barcelona (ES); Juan Francisco Espinosa Parrilla, Badalona (ES); Noemí Virgili Treserres, Roda de Barà (ES); and Blanca Wappenhans Battestini, Barcelona (ES)
Assigned to NATAC BIOTECH, S.L., Madrid (ES)
Appl. No. 14/897,948
Filed by NATAC BIOTECH, S.L, Madrid (ES)
PCT Filed Jun. 12, 2014, PCT No. PCT/EP2014/062269
§ 371(c)(1), (2) Date Dec. 11, 2015,
PCT Pub. No. WO2014/198842, PCT Pub. Date Dec. 18, 2014.
Claims priority of application No. 13171906 (EP), filed on Jun. 13, 2013.
Prior Publication US 2016/0143930 A1, May 26, 2016
Int. Cl. A61K 31/7034 (2006.01); A61K 31/05 (2006.01); A61K 31/19 (2006.01); A61K 31/191 (2006.01); A61K 31/7048 (2006.01); A61K 9/00 (2006.01); A61K 31/047 (2006.01); A61K 31/085 (2006.01); A23L 33/10 (2016.01)
CPC A61K 31/7034 (2013.01) [A23L 33/10 (2016.08); A61K 9/0053 (2013.01); A61K 31/047 (2013.01); A61K 31/05 (2013.01); A61K 31/085 (2013.01); A61K 31/19 (2013.01); A61K 31/191 (2013.01); A61K 31/7048 (2013.01)] 5 Claims
 
1. A composition comprising:
a) 1, 2, 3, 4, or 5 compounds selected from the group consisting of oleanolic acid, maslinic acid, ursolic acid, erythtodiol and uvaol;
or pharmaceutically acceptable salts thereof; and
b) 1, 2 or 3 compounds selected from the group consisting of hydroxytyrosol, verbascoside, and 3,4-dihydroxyphenylglycol;
or pharmaceutically acceptable salts thereof;
wherein the weight of the compounds of (a) with respect to the weight of the compounds of (b) is in the range from 10:1 to 1:1;
with the provisos that:
the product comprises 3,4-dihydroxyphenylglycol,
when the product comprises oleanolic acid and hydroxytyrosol, then the weight of oleanolic acid is at least 3 times the weight of hydroxytyrosol; and
when the product comprises hydroxytyrosol, maslinic acid and oleanolic acid in a weight ratio maslinic acid/oleanolic acid greater than 1, then the weight of maslinic acid is at least 10 times the weight of hydroxytyrosol.