US 10,376,523 B2
Aqueous composition containing ripasudil, or a salt, or a solvate thereof
Shin Sugimoto, Fuji (JP)
Assigned to KOWA COMPANY, LTD., Nagoya-shi (JP)
Appl. No. 15/514,259
Filed by KOWA COMPANY, LTD., Nagoya-shi (JP)
PCT Filed Sep. 25, 2015, PCT No. PCT/JP2015/077013
§ 371(c)(1), (2) Date Mar. 24, 2017,
PCT Pub. No. WO2016/047719, PCT Pub. Date Mar. 31, 2016.
Claims priority of application No. 2014-194679 (JP), filed on Sep. 25, 2014.
Prior Publication US 2017/0290841 A1, Oct. 12, 2017
Int. Cl. A61K 31/551 (2006.01); A61K 47/18 (2017.01); A61K 9/08 (2006.01); A61P 27/02 (2006.01); A61K 9/00 (2006.01); A61K 31/435 (2006.01); A61K 33/42 (2006.01)
CPC A61K 31/551 (2013.01) [A61K 9/0048 (2013.01); A61K 9/08 (2013.01); A61K 31/435 (2013.01); A61K 33/42 (2013.01); A61K 47/18 (2013.01)] 9 Claims
 
1. An aqueous composition, comprising:
ripasudil, or a salt thereof, or a solvate of ripasudil or the salt thereof; and
benzalkonium chloride,
wherein the composition does not contain brinzolamide,
and wherein a content of the benzalkonium chloride is from 0.0002 part by mass to 0.0025 part by mass, relative to 1 part by mass of the ripasudil, or a salt thereof, or a solvate of ripasudil or the salt thereof.