US 10,376,521 B2
Nutraceutical co-crystal compositions
Michael John Zaworotko, Parteen (IE); Heather Clarke, Tampa, FL (US); Arora Kapildev, Niantic, CT (US); Padmini Kavuru, Fitchburg, MA (US); Roland Douglas Shytle, Largo, FL (US); Twarita Pujari, Tampa, FL (US); Lissette Marshall, Tampa, FL (US); and Tien Teng Ong, Singapore (SG)
Assigned to University of South Florida, Tampa, FL (US)
Filed on Nov. 5, 2014, as Appl. No. 14/533,255.
Application 14/533,255 is a continuation of application No. 12/663,212, abandoned, previously published as PCT/US2008/007129, filed on Jun. 6, 2008.
Claims priority of provisional application 60/982,619, filed on Oct. 25, 2007.
Claims priority of provisional application 60/942,355, filed on Jun. 6, 2007.
Prior Publication US 2015/0250797 A1, Sep. 10, 2015
Int. Cl. A23L 33/10 (2016.01); A61K 31/20 (2006.01); A61K 31/55 (2006.01); A61K 31/197 (2006.01); A61K 31/375 (2006.01); A61K 31/455 (2006.01); A61K 31/522 (2006.01); C07D 401/14 (2006.01)
CPC A61K 31/55 (2013.01) [A23L 33/10 (2016.08); A61K 31/197 (2013.01); A61K 31/20 (2013.01); A61K 31/375 (2013.01); A61K 31/455 (2013.01); A61K 31/522 (2013.01); C07D 401/14 (2013.01)] 20 Claims
1. A composition comprising a co-crystal of a nutraceutical and a co-crystal former, the co-crystal with or without impurities wherein (i) the nutraceutical and the co-crystal former are hydrogen bonded to each other, (ii) the nutraceutical is selected from the group consisting of vitamin B2 (riboflavin), glucosamine HCl, chlorogenic acid, lipoic acid, catechin hydrate, creatine, acetyl-L-carnitine HCl, vitamin B6, pyridoxine, caffeic acid, naringenin, vitamin B1 (thiamine HCl), baicalein, luteolin, hesperedin, rosmarinic acid, epicatechin gallate, epigallocatechin, vitamin B9 (folic), genistein, methylvanillin, ethylvanillin, silibinin, diadzein, melatonin, rutin hydrate, vitamin A, retinol, vitamin D2 (ergocalciferol), vitamin E (tocopherol), diosmin, menadione (K3), vitamin D3 (caholecalciferol), phloretin, indole-3-carbinol, fisetin, glycitein, chrysin, gallocatechin, vitamin B4 (adenine), vitamin B5 (pantothenic acid), vitamin B7 (biotin), theobromine, quercetin, ferulic acid, ellagic acid, hesperitin, and protocatechuic acid, and (iii) a co-crystal former selected from the group consisting of pharmaceutically acceptable carbohydrates, amines, amides, sulfonamides, carboxylic acids, sulfonic acids, phenols, polyphenols, aromatic heterocycles, xanthines and alcohols.