US 10,376,520 B2
Methods for the treatment of cardiovascular disorders
Piet Tom Bert Paul Wigerinck, Mechelen (BE); and Gerben Albert Eleutherius Van 'T Klooster, Mechelen (BE)
Assigned to GALAPAGOS NV, Mechelen (BE)
Appl. No. 15/566,002
Filed by Galapagos NV, Mechelen (BE)
PCT Filed Mar. 31, 2016, PCT No. PCT/EP2016/057103
§ 371(c)(1), (2) Date Oct. 12, 2017,
PCT Pub. No. WO2016/165952, PCT Pub. Date Oct. 20, 2016.
Claims priority of application No. 1506228.4 (GB), filed on Apr. 13, 2015; application No. 1507109.5 (GB), filed on Apr. 27, 2015; application No. 1513344 (GB), filed on Jul. 29, 2015; application No. 1513991.8 (GB), filed on Aug. 7, 2015; and application No. 1521542.9 (GB), filed on Dec. 7, 2015.
Prior Publication US 2018/0185377 A1, Jul. 5, 2018
Int. Cl. A61K 31/541 (2006.01); A61P 9/10 (2006.01); A61P 3/06 (2006.01); A61K 45/06 (2006.01); A61K 31/54 (2006.01)
CPC A61K 31/541 (2013.01) [A61K 31/54 (2013.01); A61K 45/06 (2013.01); A61P 3/06 (2018.01); A61P 9/10 (2018.01)] 33 Claims
 
1. A method for the prophylaxis and/or treatment of cardiovascular disorders and/or dyslipidemia, comprising:
administering to a patient in need thereof an effective amount of a compound according to Formula I:

OG Complex Work Unit Drawing
or a pharmaceutically acceptable salt thereof, or a solvate or the salt of a solvate thereof, or an active metabolite thereof.