US 10,376,517 B2
Methods of synthesizing thyroid hormone analogs and polymorphs thereof
Rebecca Taub, Villanova, PA (US); Charles H. Reynolds, Lansdale, PA (US); Lianhe Shu, Livingston, NJ (US); Ping Wang, Nutley, NJ (US); and Duk Soon Choi, Flanders, NJ (US)
Assigned to Madrigal Pharmaceuticals, Inc., West Conshohocken, PA (US); and Hoffmann-La Roche Inc., Little Falls, NJ (US)
Filed by Madrigal Pharmaceuticals, Inc., West Conshohocken, PA (US); and Hoffman-La Roche Inc., Little Falls, NJ (US)
Filed on Apr. 10, 2018, as Appl. No. 15/949,389.
Application 15/046,213 is a division of application No. 14/660,720, filed on Mar. 17, 2015, granted, now 9,266,861, issued on Feb. 23, 2016.
Application 15/949,389 is a continuation of application No. 15/046,213, filed on Feb. 17, 2016, granted, now 9,968,612.
Application 14/660,720 is a continuation of application No. PCT/US2013/060177, filed on Sep. 17, 2013.
Claims priority of provisional application 61/702,137, filed on Sep. 17, 2012.
Claims priority of provisional application 61/790,432, filed on Mar. 15, 2013.
Prior Publication US 2018/0228807 A1, Aug. 16, 2018
This patent is subject to a terminal disclaimer.
Int. Cl. C07D 237/16 (2006.01); C07D 403/12 (2006.01); A61K 31/50 (2006.01); A61K 31/53 (2006.01); C07D 403/02 (2006.01); A61P 5/14 (2006.01); A61P 9/00 (2006.01)
CPC A61K 31/53 (2013.01) [A61K 31/50 (2013.01); A61P 5/14 (2018.01); A61P 9/00 (2018.01); C07D 237/16 (2013.01); C07D 403/02 (2013.01); C07D 403/12 (2013.01); C07B 2200/13 (2013.01); Y02P 20/55 (2015.11)] 25 Claims
 
1. A morphic form of 2-(3,5-dichloro-4-((5-isopropyl-6-oxo-1,6-dihydropyridazin-3-yl)oxy)phenyl)-3,5-dioxo-2,3,4,5-tetrahydro-1,2,4-triazine-6-carbonitrile (“Compound A”), wherein the morphic form is a hydrate.