US 10,376,515 B2
Analogs of adenosine monophosphate (AMP) as inhibitors of ubiquitin-like modifier-activating enzyme ATG7
Alexander V. Statsyuk, Evanston, IL (US); and Heeseon An, Evanston, IL (US)
Assigned to NORTHWESTERN UNIVERSITY, Evanston, IL (US)
Filed by Northwestern University, Evanston, IL (US)
Filed on May 2, 2017, as Appl. No. 15/584,806.
Claims priority of provisional application 62/330,539, filed on May 2, 2016.
Prior Publication US 2017/0312284 A1, Nov. 2, 2017
Int. Cl. A01N 43/04 (2006.01); A61K 31/70 (2006.01); A61K 31/52 (2006.01); A61K 31/131 (2006.01); A61K 31/133 (2006.01); A61K 31/135 (2006.01); A61K 31/695 (2006.01); A61K 31/365 (2006.01); A61K 45/00 (2006.01); C07D 471/04 (2006.01); C07H 19/14 (2006.01); A61K 31/708 (2006.01); A61K 31/7076 (2006.01); C07H 19/23 (2006.01); C07H 19/22 (2006.01)
CPC A61K 31/52 (2013.01) [A61K 31/131 (2013.01); A61K 31/133 (2013.01); A61K 31/135 (2013.01); A61K 31/365 (2013.01); A61K 31/695 (2013.01); A61K 45/05 (2013.01); C07D 471/04 (2013.01); A61K 31/708 (2013.01); A61K 31/7076 (2013.01); C07H 19/14 (2013.01); C07H 19/22 (2013.01); C07H 19/23 (2013.01)] 14 Claims
 
1. A compound of Formula Ib′:

OG Complex Work Unit Drawing
wherein:
X is CH2, NH, O, or S;
Y is an electrophile;
or Y and X together form a 3-membered, 4-membered, 5-membered, 6-membered, or 7-membered carbocycle or heterocycle which optionally is unsaturated at one or more bonds and which optionally includes a carbonyl substituent.