US 10,376,495 B2
Small molecules that mimic or antagonize actions of granulocyte colony-stimulating-factor (G-CSF)
Juan Sanchez-Ramos, Plant City, FL (US); Vasyl Sava, Wesley Chapel, FL (US); Shijie Song, Tampa, FL (US); and Said Sebti, Tampa, FL (US)
Assigned to University of South Florida, Tampa, FL (US); The United States Government as Represented by the Department of Veterans, Washington, DC (US); and H. Lee Moffitt Cancer Center and research Institute Inc., Tampa, FL (US)
Filed by UNIVERSITY OF SOUTH FLORIDA, Tampa, FL (US); THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS, Washington, DC (US); and H. LEE MOFFITT CANCER CENTER AND RESEARCH INSTRITUTE INC., Tampa, FL (US)
Filed on Nov. 22, 2017, as Appl. No. 15/821,634.
Claims priority of provisional application 62/426,032, filed on Nov. 23, 2016.
Prior Publication US 2018/0177763 A1, Jun. 28, 2018
Int. Cl. A61K 31/4174 (2006.01); C07D 233/60 (2006.01); A61K 31/53 (2006.01); A61K 38/19 (2006.01); A61P 25/28 (2006.01)
CPC A61K 31/4174 (2013.01) [A61K 31/53 (2013.01); A61K 38/193 (2013.01); A61P 25/28 (2018.01); C07D 233/60 (2013.01)] 12 Claims
 
1. A method of treating a condition in a subject, the method comprising administering a compound to the subject,
wherein the compound is

OG Complex Work Unit Drawing
wherein the condition is selected from the group consisting of neurodegenerative disease, stroke, traumatic brain injury (TBI), impaired motor function, and impaired cognitive function.