US 10,376,492 B2
Use of a macrocyclic lactone for treating a complication from a papilloma virus infection
Jean Jacovella, Antibes (FR)
Assigned to GALDERMA S.A., Cham (CH)
Appl. No. 14/780,314
Filed by GALDERMA S.A., Cham (CH)
PCT Filed Mar. 28, 2014, PCT No. PCT/EP2014/056374
§ 371(c)(1), (2) Date Sep. 25, 2015,
PCT Pub. No. WO2014/154899, PCT Pub. Date Oct. 2, 2014.
Claims priority of application No. 13 52855 (FR), filed on Mar. 29, 2013.
Prior Publication US 2016/0051508 A1, Feb. 25, 2016
Int. Cl. A61K 31/365 (2006.01); A61K 31/7048 (2006.01)
CPC A61K 31/365 (2013.01) [A61K 31/7048 (2013.01)] 18 Claims
1. A method of treating a complication of an infection by a human papilloma virus selected from the group consisting of vaginal intraepithelial neoplasias, cervical intraepithelial neoplasias, and cervical dysplasias, the method comprising administering topically a pharmaceutical composition comprising from 100 μg to 500 mg of an avermectin, milbemycin, or pharmaceutically acceptable salt thereof, to an adult human patient in need thereof.